MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F17%3A73583631" target="_blank" >RIV/61989592:15310/17:73583631 - isvavai.cz</a>

Výsledek na webu

<a href="https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1261-8" target="_blank" >https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1261-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13059-017-1261-8" target="_blank" >10.1186/s13059-017-1261-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

Popis výsledku v původním jazyce

Background: Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level. Results: Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase. Conclusions: By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.

Název v anglickém jazyce

MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

Popis výsledku anglicky

Background: Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level. Results: Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase. Conclusions: By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10611 - Plant sciences, botany

Projekt

<a href="/cs/project/GA16-22044S" target="_blank" >GA16-22044S: Funkční regulace fosfolipasy D alfa 1 prostřednictvím MPK3-závislé fosforylace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Genome Biology

ISSN

1474-760X

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

JUL 6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

19

Strana od-do

131

Kód UT WoS článku

000404869300001

EID výsledku v databázi Scopus

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