Effect of corn lectins on the intestinal transport of trace elements

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73598977" target="_blank" >RIV/61989592:15310/19:73598977 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007%2Fs00003-019-01261-1" target="_blank" >https://link.springer.com/article/10.1007%2Fs00003-019-01261-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00003-019-01261-1" target="_blank" >10.1007/s00003-019-01261-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of corn lectins on the intestinal transport of trace elements

Popis výsledku v původním jazyce

The absorption of iron, copper, zinc, and cobalt deriving from the diet and supplements varies, depending on the form of these trace elements and the presence of absorption inhibitors. The objective of this study was to examine the absorption of iron, copper, zinc, and cobalt in the presence of corn lectin as a possible inhibitor of intestinal absorption. The highest level of inhibition was shown in bull in vitro intestinal segments: incubation with corn lectins reduced the absorption of copper by 35.5%, of zinc by 28%, and of cobalt by 17.3%. It caused no observable effect on iron absorption. The addition of N-acetylgalactosamine neutralised the inhibitory effect of corn lectins and restored the absorption of the trace elements. The levels of copper and iron in the blood of rats receiving a diet supplemented with lyophilized corn lectins, decreased by 11.3% and 16.4%, respectively. Our results thus suggest that corn lectins may act as absorption inhibitors of iron, copper, zinc, and cobalt, most likely through blocking the transport of elements across the apical membrane of enterocytes. The present study suggests that individuals should consider their trace element status if their diet includes high amounts of raw corn. However, additional in vivo studies are required to confirm these results.

Název v anglickém jazyce

Effect of corn lectins on the intestinal transport of trace elements

Popis výsledku anglicky

The absorption of iron, copper, zinc, and cobalt deriving from the diet and supplements varies, depending on the form of these trace elements and the presence of absorption inhibitors. The objective of this study was to examine the absorption of iron, copper, zinc, and cobalt in the presence of corn lectin as a possible inhibitor of intestinal absorption. The highest level of inhibition was shown in bull in vitro intestinal segments: incubation with corn lectins reduced the absorption of copper by 35.5%, of zinc by 28%, and of cobalt by 17.3%. It caused no observable effect on iron absorption. The addition of N-acetylgalactosamine neutralised the inhibitory effect of corn lectins and restored the absorption of the trace elements. The levels of copper and iron in the blood of rats receiving a diet supplemented with lyophilized corn lectins, decreased by 11.3% and 16.4%, respectively. Our results thus suggest that corn lectins may act as absorption inhibitors of iron, copper, zinc, and cobalt, most likely through blocking the transport of elements across the apical membrane of enterocytes. The present study suggests that individuals should consider their trace element status if their diet includes high amounts of raw corn. However, additional in vivo studies are required to confirm these results.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10620 - Other biological topics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Consumer Protection and Food Safety

ISSN

1661-5751

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

163-170

Kód UT WoS článku

000533077700008

EID výsledku v databázi Scopus

2-s2.0-85075930508