Deciphering the Peculiar Behavior of beta-Lapachone in Lipid Monolayers and Bilayers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73600630" target="_blank" >RIV/61989592:15310/19:73600630 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/full/10.1021/acs.langmuir.9b02886" target="_blank" >https://pubs.acs.org/doi/full/10.1021/acs.langmuir.9b02886</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.langmuir.9b02886" target="_blank" >10.1021/acs.langmuir.9b02886</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deciphering the Peculiar Behavior of beta-Lapachone in Lipid Monolayers and Bilayers

Popis výsledku v původním jazyce

beta-Lapachone (beta-Lap) is a promising anticancer drug whose applications have been limited so far because of its poor solubility and stability. Its encapsulation in liposomes has been proposed to overcome these issues. However, surface pressure measurements show that beta-Lap exhibits atypical interfacial behavior when mixed with lipids. Although the drug does not seem to be retained in lipid monolayers as deduced from the pi-A isotherms, small changes in compressibility moduli suggest that beta-Lap actually interacts with lipids, either disorganizing or rigidifying their monolayers. Thermal and structural analyses of lipid bilayers confirm the existence of beta-Lap/lipid interactions and show that the drug inserts between hydrophobic chains, close to the polar headgroup in DPPC bilayers and deeper in the acyl chains in POPC bilayers. Molecular dynamics simulations allow a comprehensive description of the drug position and orientation in DOPC and POPC bilayers in the presence or absence of cholesterol.

Název v anglickém jazyce

Deciphering the Peculiar Behavior of beta-Lapachone in Lipid Monolayers and Bilayers

Popis výsledku anglicky

beta-Lapachone (beta-Lap) is a promising anticancer drug whose applications have been limited so far because of its poor solubility and stability. Its encapsulation in liposomes has been proposed to overcome these issues. However, surface pressure measurements show that beta-Lap exhibits atypical interfacial behavior when mixed with lipids. Although the drug does not seem to be retained in lipid monolayers as deduced from the pi-A isotherms, small changes in compressibility moduli suggest that beta-Lap actually interacts with lipids, either disorganizing or rigidifying their monolayers. Thermal and structural analyses of lipid bilayers confirm the existence of beta-Lap/lipid interactions and show that the drug inserts between hydrophobic chains, close to the polar headgroup in DPPC bilayers and deeper in the acyl chains in POPC bilayers. Molecular dynamics simulations allow a comprehensive description of the drug position and orientation in DOPC and POPC bilayers in the presence or absence of cholesterol.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

LANGMUIR

ISSN

0743-7463

e-ISSN

—

Svazek periodika

35

Číslo periodika v rámci svazku

45

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

14603-14615

Kód UT WoS článku

000497262300023

EID výsledku v databázi Scopus

2-s2.0-85074578219