Biotechnological applications of nanostructured hybrids of polyamine carbon quantum dots and iron oxide nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73601438" target="_blank" >RIV/61989592:15310/20:73601438 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00726-019-02721-6" target="_blank" >https://link.springer.com/article/10.1007/s00726-019-02721-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00726-019-02721-6" target="_blank" >10.1007/s00726-019-02721-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biotechnological applications of nanostructured hybrids of polyamine carbon quantum dots and iron oxide nanoparticles

Popis výsledku v původním jazyce

The combination of different nanomaterials has been investigated during the past few decades and represents an exciting challenge for the unexpected emerging properties of the resulting nano-hybrids. Spermidine (Spd), a biogenic polyamine, has emerged as a useful functional monomer for the development of carbon quantum dots (CQDs). Herein, an electrostatically stabilized ternary hybrid, constituted of iron oxide-DNA (the core) and spermidine carbon quantum dots (CQD(Spds), the shell), was self-assembled and fully characterized. The as-obtained nano-hybrid was tested on HeLa cells to evaluate its biocompatibility as well as cellular uptake. Most importantly, besides being endowed by the magnetic features of the core, it displayed drastically enhanced fluorescence properties in comparison with parent CQD(Spds) and it is efficiently internalized by HeLa cells. This novel ternary nano-hybrid with multifaceted properties, ranging from fluorescence to superparamagnetism, represents an interesting option for cell tracking.

Název v anglickém jazyce

Biotechnological applications of nanostructured hybrids of polyamine carbon quantum dots and iron oxide nanoparticles

Popis výsledku anglicky

The combination of different nanomaterials has been investigated during the past few decades and represents an exciting challenge for the unexpected emerging properties of the resulting nano-hybrids. Spermidine (Spd), a biogenic polyamine, has emerged as a useful functional monomer for the development of carbon quantum dots (CQDs). Herein, an electrostatically stabilized ternary hybrid, constituted of iron oxide-DNA (the core) and spermidine carbon quantum dots (CQD(Spds), the shell), was self-assembled and fully characterized. The as-obtained nano-hybrid was tested on HeLa cells to evaluate its biocompatibility as well as cellular uptake. Most importantly, besides being endowed by the magnetic features of the core, it displayed drastically enhanced fluorescence properties in comparison with parent CQD(Spds) and it is efficiently internalized by HeLa cells. This novel ternary nano-hybrid with multifaceted properties, ranging from fluorescence to superparamagnetism, represents an interesting option for cell tracking.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LO1204" target="_blank" >LO1204: Udržitelný rozvoj výzkumu v Centru regionu Haná</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

AMINO ACIDS

ISSN

0939-4451

e-ISSN

—

Svazek periodika

52

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

11

Strana od-do

301-311

Kód UT WoS článku

000519385700017

EID výsledku v databázi Scopus

2-s2.0-85064275104