Electrochemical oxidation of anti-inflammatory drug meloxicam and its determination using boron doped diamond electrode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73603855" target="_blank" >RIV/61989592:15310/20:73603855 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216275:25310/20:39916369

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1572665719310264" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1572665719310264</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jelechem.2019.113758" target="_blank" >10.1016/j.jelechem.2019.113758</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemical oxidation of anti-inflammatory drug meloxicam and its determination using boron doped diamond electrode

Popis výsledku v původním jazyce

Voltammetric behavior of a nonsteroidal anti-inflammatory drug meloxicam was firstly studied using boron doped diamond electrode (BDDE). Two irreversible anodic current peaks were observed in wide pH range at potentials +900 mV and +1400 mV vs. saturated silver-silver chloride electrode. Mechanism of the electrochemical oxidation was proposed and confirmed using high performance liquid chromatography/mass spectrometry analysis of electrolyzed meloxicam solutions. Subsequently, an analytical method for meloxicam determination was developed using differential pulse voltammetry in connection with BDDE. This method provides low limit of detection (5.9 x 10(-8) mol L-1) and wide linear dynamic range (2.5 x 10(-7)-8.5 x 10(-5) mol L-1). Finally, model solutions as well as pharmaceutical preparations were successfully analyzed, and the meloxicam content was determined.

Název v anglickém jazyce

Electrochemical oxidation of anti-inflammatory drug meloxicam and its determination using boron doped diamond electrode

Popis výsledku anglicky

Voltammetric behavior of a nonsteroidal anti-inflammatory drug meloxicam was firstly studied using boron doped diamond electrode (BDDE). Two irreversible anodic current peaks were observed in wide pH range at potentials +900 mV and +1400 mV vs. saturated silver-silver chloride electrode. Mechanism of the electrochemical oxidation was proposed and confirmed using high performance liquid chromatography/mass spectrometry analysis of electrolyzed meloxicam solutions. Subsequently, an analytical method for meloxicam determination was developed using differential pulse voltammetry in connection with BDDE. This method provides low limit of detection (5.9 x 10(-8) mol L-1) and wide linear dynamic range (2.5 x 10(-7)-8.5 x 10(-5) mol L-1). Finally, model solutions as well as pharmaceutical preparations were successfully analyzed, and the meloxicam content was determined.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/GA17-03868S" target="_blank" >GA17-03868S: Nové metody elektrochemického sledování biologicky aktivních organických látek v environmentálních, biologických a potravinových matricích</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF ELECTROANALYTICAL CHEMISTRY

ISSN

1572-6657

e-ISSN

—

Svazek periodika

858

Číslo periodika v rámci svazku

FEB

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

"113758-1"-"113758-9"

Kód UT WoS článku

000515205600004

EID výsledku v databázi Scopus

2-s2.0-85076893090