Dinuclear doubly bridged phenoxido copper(II) complexes as efficient anticancer agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F23%3A73617077" target="_blank" >RIV/61989592:15310/23:73617077 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/23:73617077

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0223523422008947?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0223523422008947?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejmech.2022.114992" target="_blank" >10.1016/j.ejmech.2022.114992</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dinuclear doubly bridged phenoxido copper(II) complexes as efficient anticancer agents

Popis výsledku v původním jazyce

Two cationic [Cu-2(L1-2)(2)](ClO4)(2) (1, 2), and four neutral doubly bridged-phenoxido-copper(II) complexes [Cu-2(L3-4)(2)] (3, 4) and [Cu-2(L5-6)(2)(H2O)center dot 2H(2)O (5, 6) as well as 1D polymeric catena-[Cu(L-7)] (7), where HL1-2 and H2L3-7 represent tripodal tetradentate pyridyl or aliphatic-amino groups based 2,4-disubstituted phenolates, were synthesized and thoroughly characterized by various spectroscopic methods and single crystal X-ray analysis. The molecular structures of the complexes exhibited diverse geometrical environments around the central Cu(II) atoms. The in vitro antiproliferative activity of the isolated complexes and selected parent free ligands were screened against some human cancer cell lines (A2780, A2780R, PC-3, 22Rv1, MCF-7). The most promising cytotoxicity against cancer cells were obtained for 1-6, while complex 6 was found as the best per-forming as compared to the reference drug cisplatin. The cytotoxicity study of complex 6 was therefore extended to wider variety of cancer cell lines (HOS, A549, PANC-1, CaCo2, HeLa) and results revealed its significant cytotoxicity on all investigated human cancer cells. The cell uptake study showed that cytotoxicity of 6 (3 mu M concentration and 24 h of incubation) against A2780 cells was almost independent from the intracellular levels of copper. The effect of complexes 4, 6 and 7 on cell cycle of A2780 cells indicates that the mechanism of action in these complexes is not only different from that of cisplatin but also different among them. Complex 7 was able to induce apoptosis in A2780 cells, while complexes 4 and 6 did not and on the other hand, they showed considerable effect on autophagy induction and there are some clues that these complexes were able to induce cuproptosis in A2780 cells.

Název v anglickém jazyce

Dinuclear doubly bridged phenoxido copper(II) complexes as efficient anticancer agents

Popis výsledku anglicky

Two cationic [Cu-2(L1-2)(2)](ClO4)(2) (1, 2), and four neutral doubly bridged-phenoxido-copper(II) complexes [Cu-2(L3-4)(2)] (3, 4) and [Cu-2(L5-6)(2)(H2O)center dot 2H(2)O (5, 6) as well as 1D polymeric catena-[Cu(L-7)] (7), where HL1-2 and H2L3-7 represent tripodal tetradentate pyridyl or aliphatic-amino groups based 2,4-disubstituted phenolates, were synthesized and thoroughly characterized by various spectroscopic methods and single crystal X-ray analysis. The molecular structures of the complexes exhibited diverse geometrical environments around the central Cu(II) atoms. The in vitro antiproliferative activity of the isolated complexes and selected parent free ligands were screened against some human cancer cell lines (A2780, A2780R, PC-3, 22Rv1, MCF-7). The most promising cytotoxicity against cancer cells were obtained for 1-6, while complex 6 was found as the best per-forming as compared to the reference drug cisplatin. The cytotoxicity study of complex 6 was therefore extended to wider variety of cancer cell lines (HOS, A549, PANC-1, CaCo2, HeLa) and results revealed its significant cytotoxicity on all investigated human cancer cells. The cell uptake study showed that cytotoxicity of 6 (3 mu M concentration and 24 h of incubation) against A2780 cells was almost independent from the intracellular levels of copper. The effect of complexes 4, 6 and 7 on cell cycle of A2780 cells indicates that the mechanism of action in these complexes is not only different from that of cisplatin but also different among them. Complex 7 was able to induce apoptosis in A2780 cells, while complexes 4 and 6 did not and on the other hand, they showed considerable effect on autophagy induction and there are some clues that these complexes were able to induce cuproptosis in A2780 cells.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/EF16_019%2F0000754" target="_blank" >EF16_019/0000754: Nanotechnologie pro budoucnost</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ISSN

0223-5234

e-ISSN

1768-3254

Svazek periodika

246

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

13

Strana od-do

—

Kód UT WoS článku

000902003000005

EID výsledku v databázi Scopus

2-s2.0-85144060026