Skatole: A thin red line between its benefits and toxicity

Kód výsledku v IS VaVaI

RIV/61989592:15310/23:73619465 - isvavai.cz

Výsledek na webu

https://www.sciencedirect.com/science/article/pii/S030090842200339X?via%3Dihub

DOI - Digital Object Identifier

10.1016/j.biochi.2022.12.014

Jazyk výsledku

angličtina

Název v původním jazyce

Skatole: A thin red line between its benefits and toxicity

Popis výsledku v původním jazyce

Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and is produced by certain flowers. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream. Additionally, skatole is formed by tryptophan pyrolysis of tobacco and has been demonstrated to be a mutagen. Skatole-induced pulmonotoxicity was reliably described in ruminants and rodents, but no studies have been conducted in humans. Initially, we provide basic knowledge and a historical overview of skatole. Then, skatole bacterial formation in the intestine is described, and the importance of the microbiome during this process is evaluated. Increased skatole concentrations could serve as a marker for intestinal disease development. Therefore, the human molecular targets of skatole that may have significant effects on various processes in the human body are described. Ultimately, we suggest a link between skatole intestinal formation in humans and skatole-induced pulmonotoxicity, which should be explored further in the future.

Název v anglickém jazyce

Skatole: A thin red line between its benefits and toxicity

Popis výsledku anglicky

Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and is produced by certain flowers. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream. Additionally, skatole is formed by tryptophan pyrolysis of tobacco and has been demonstrated to be a mutagen. Skatole-induced pulmonotoxicity was reliably described in ruminants and rodents, but no studies have been conducted in humans. Initially, we provide basic knowledge and a historical overview of skatole. Then, skatole bacterial formation in the intestine is described, and the importance of the microbiome during this process is evaluated. Increased skatole concentrations could serve as a marker for intestinal disease development. Therefore, the human molecular targets of skatole that may have significant effects on various processes in the human body are described. Ultimately, we suggest a link between skatole intestinal formation in humans and skatole-induced pulmonotoxicity, which should be explored further in the future.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

NV19-05-00220: Aktivátory lidského aryl uhlovodíkového receptoru (AhR) v terapii nespecifických střevních zánětů

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOCHIMIE

ISSN

0300-9084

e-ISSN

1638-6183

Svazek periodika

208

Číslo periodika v rámci svazku

MAY

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

12

Strana od-do

1-12

Kód UT WoS článku

001011334300001

EID výsledku v databázi Scopus

2-s2.0-85146091380