MXenes for Cancer Therapy and Diagnosis: Recent Advances and Current Challenges

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F21%3A73607179" target="_blank" >RIV/61989592:15640/21:73607179 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsbiomaterials.0c01763" target="_blank" >https://pubs.acs.org/doi/10.1021/acsbiomaterials.0c01763</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsbiomaterials.0c01763" target="_blank" >10.1021/acsbiomaterials.0c01763</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MXenes for Cancer Therapy and Diagnosis: Recent Advances and Current Challenges

Popis výsledku v původním jazyce

MXenes endowed with several attractive physicochemical attributes, namely, specific large surface area, significant electrical conductivity, magnetism, low toxicity, luminescence, and high biocompatibility, have been considered as promising candidates for cancer therapy and theranostics. These two-dimensional (2D) nanostructures endowed with photothermal, chemotherapeutic synergistic, and photodynamic effects have shown promising potential for decidedly effectual and noninvasive anticancer treatments. They have been explored for photothermal/chemo-photothermal therapy (PTT) and for targeted anticancer drug delivery. Remarkably, MXenes with their unique optical properties have been employed for bioimaging and biosensing, and their excellent light-to-heat transition competence renders them an ideal biocompatible and decidedly proficient nanoscaled agent for PTT appliances. However, several important challenging issues still linger regarding their stability in physiological environments, sustained/controlled release of drugs, and biodegradability that need to be addressed. This Perspective emphasizes the latest advancements of MXenes and MXene-based materials in the domain of targeted cancer therapy/diagnosis, with a focus on the current trends, important challenges, and future perspectives.

Název v anglickém jazyce

MXenes for Cancer Therapy and Diagnosis: Recent Advances and Current Challenges

Popis výsledku anglicky

MXenes endowed with several attractive physicochemical attributes, namely, specific large surface area, significant electrical conductivity, magnetism, low toxicity, luminescence, and high biocompatibility, have been considered as promising candidates for cancer therapy and theranostics. These two-dimensional (2D) nanostructures endowed with photothermal, chemotherapeutic synergistic, and photodynamic effects have shown promising potential for decidedly effectual and noninvasive anticancer treatments. They have been explored for photothermal/chemo-photothermal therapy (PTT) and for targeted anticancer drug delivery. Remarkably, MXenes with their unique optical properties have been employed for bioimaging and biosensing, and their excellent light-to-heat transition competence renders them an ideal biocompatible and decidedly proficient nanoscaled agent for PTT appliances. However, several important challenging issues still linger regarding their stability in physiological environments, sustained/controlled release of drugs, and biodegradability that need to be addressed. This Perspective emphasizes the latest advancements of MXenes and MXene-based materials in the domain of targeted cancer therapy/diagnosis, with a focus on the current trends, important challenges, and future perspectives.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Biomaterials Science &amp; Engineering

ISSN

2373-9878

e-ISSN

—

Svazek periodika

2021

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

1900-1913

Kód UT WoS článku

000662265300001

EID výsledku v databázi Scopus

2-s2.0-85105101661