Studium vazby cytostatik na bázi platiny do DNA struktury: Terapeutická koncentrace cytostatik na bázi platiny

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00086666" target="_blank" >RIV/62156489:43210/05:00086666 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of Binding of Platinum Cytostatic to DNA Structure: Therapeutic Concentration of Platinum Cytostatic

Popis výsledku v původním jazyce

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes[1]. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding toproteins (e.g. metallothionein). The metallothionein (MT) family is a class of low molecular weight, intracellular and cysteine-rich proteins presenting high affinity for metal ions[2]. Metallothionein is a well-known heavy metal binding protein maintaining metal ion homeostasis[3]. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak)[4]. Our suggested technique was used for analysis of blood serum of the patients treated with standard platinum compounds. The MT amount increased in this patients' serum more tha

Název v anglickém jazyce

Study of Binding of Platinum Cytostatic to DNA Structure: Therapeutic Concentration of Platinum Cytostatic

Popis výsledku anglicky

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes[1]. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding toproteins (e.g. metallothionein). The metallothionein (MT) family is a class of low molecular weight, intracellular and cysteine-rich proteins presenting high affinity for metal ions[2]. Metallothionein is a well-known heavy metal binding protein maintaining metal ion homeostasis[3]. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak)[4]. Our suggested technique was used for analysis of blood serum of the patients treated with standard platinum compounds. The MT amount increased in this patients' serum more tha

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Studium obranných mechanismů rostlin při stresu způsobeném těžkými kovy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

45th Annual Meeting of The American Society for Cell Biology

ISBN

1059-1524

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

"382a"-382a"

Název nakladatele

The American Society for Cell Biology

Místo vydání

San Francisco, USA

Místo konání akce

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Datum konání akce

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Typ akce podle státní příslušnosti

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Kód UT WoS článku

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