Vliv léků na bázi platiny na množství metalothionein

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00086818" target="_blank" >RIV/62156489:43210/05:00086818 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The influence of platinum-based drugs on the amount of metallothionein

Popis výsledku v původním jazyce

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding to proteins (e.g. metallothionein). Metallothionein (MT) is a well-known molecular protein maintaining metal ion homeostasis. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in our experiments invitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak). Our suggested technique was used for blood serum analysis from the patients treated with standard platinum compounds. The MT amount was increased more than 10 times in these patients'serum in comparison with non-treated patients. The results thus show that the MT amount has a significant negative influence on the therapy

Název v anglickém jazyce

The influence of platinum-based drugs on the amount of metallothionein

Popis výsledku anglicky

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug, commonly influenced by binding to proteins (e.g. metallothionein). Metallothionein (MT) is a well-known molecular protein maintaining metal ion homeostasis. The aim of this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in our experiments invitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (metallothionein-SH groups reduction, Brdicka reaction, and H-peak). Our suggested technique was used for blood serum analysis from the patients treated with standard platinum compounds. The MT amount was increased more than 10 times in these patients'serum in comparison with non-treated patients. The results thus show that the MT amount has a significant negative influence on the therapy

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Studium obranných mechanismů rostlin při stresu způsobeném těžkými kovy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology Letters

ISSN

0378-4274

e-ISSN

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Svazek periodika

158

Číslo periodika v rámci svazku

Suppl.1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

2

Strana od-do

"S66"-"S67"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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