Indukce syntézy Metalotioneinu pomocí léků založených na platině

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00086863" target="_blank" >RIV/62156489:43210/05:00086863 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Induction of Synthesis of Metallothionein by Platinum Based Drugs

Popis výsledku v původním jazyce

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug commonly influenced by binding to proteins (e.g. metallothionein). The metallothionein (MT) family is class of low molecular, intracellular and cysteine-rich proteins presenting high affinity for metal ions. Metallothionein is a well-known heavy metal binding protein maintaining metal ion homeostasis. In human organisms MTs are usually abundant at low concentrations levels. Their marked expression is caused by many exogenous and endogenous factors such as UV radiation, heavy metals, xenobiotic species, reactive oxygen species etc. The aimof this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (Brdicka reaction, and peak H).

Název v anglickém jazyce

Induction of Synthesis of Metallothionein by Platinum Based Drugs

Popis výsledku anglicky

Neoplastic diseases represent one of the most prevalent human disorders. Many of those are generally treated by platinum-complexes. Effectiveness of such treatment depends on the therapeutic concentration of the drug commonly influenced by binding to proteins (e.g. metallothionein). The metallothionein (MT) family is class of low molecular, intracellular and cysteine-rich proteins presenting high affinity for metal ions. Metallothionein is a well-known heavy metal binding protein maintaining metal ion homeostasis. In human organisms MTs are usually abundant at low concentrations levels. Their marked expression is caused by many exogenous and endogenous factors such as UV radiation, heavy metals, xenobiotic species, reactive oxygen species etc. The aimof this work was to study the interaction of MT with Pt compounds. The proper interaction was observed in vitro by means of electrochemical techniques using the oxidation-reduction and/or catalytic signals (Brdicka reaction, and peak H).

Druh

D - Stať ve sborníku

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Studium obranných mechanismů rostlin při stresu způsobeném těžkými kovy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

45th Annual Meeting of The American Society for Cell Biology

ISBN

1059-1524

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

"382a"-382a"

Název nakladatele

The American Society for Cell Biology

Místo vydání

San Francisco, USA

Místo konání akce

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Datum konání akce

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Typ akce podle státní příslušnosti

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Kód UT WoS článku

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