Studium interakce glutathionu a metalothioneinu s cytostatiky

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F06%3A00103406" target="_blank" >RIV/62156489:43210/06:00103406 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of interaction of glutathiones and metallothionein with cytostatics

Popis výsledku v původním jazyce

Glutathione and metallothionein (MT) play a key role in detoxification of chemical compounds coming to an organism. Due to their high affinity to heavy metals, homeostatic control and detoxification of the metals are one of their main physiological functions. Objective. The aim of this work was to study and characterize interactions of glutathiones (reduced GSH, oxidized GSSG and S-nitrosoglutathione GSNO) and MT with platinum group metals and cytostatics (cisplatin, carboplatin and oxaliplatin). Materials and methods. We used different electrochemical techniques (cyclic voltammetry, differential pulse voltammetry and chronopotentiometric stripping analysis). Measurements were performed with AUTOLAB connected to VA-Stand 663, using standard cell with three electrodes. We observed that signal of GSH decreased with increasing concentration of a heavy metal. Moreover, presence of heavy metals catalysed decomposition of GSNO, thus, nitric oxide was released. Conclusion. MT could markedly d

Název v anglickém jazyce

Study of interaction of glutathiones and metallothionein with cytostatics

Popis výsledku anglicky

Glutathione and metallothionein (MT) play a key role in detoxification of chemical compounds coming to an organism. Due to their high affinity to heavy metals, homeostatic control and detoxification of the metals are one of their main physiological functions. Objective. The aim of this work was to study and characterize interactions of glutathiones (reduced GSH, oxidized GSSG and S-nitrosoglutathione GSNO) and MT with platinum group metals and cytostatics (cisplatin, carboplatin and oxaliplatin). Materials and methods. We used different electrochemical techniques (cyclic voltammetry, differential pulse voltammetry and chronopotentiometric stripping analysis). Measurements were performed with AUTOLAB connected to VA-Stand 663, using standard cell with three electrodes. We observed that signal of GSH decreased with increasing concentration of a heavy metal. Moreover, presence of heavy metals catalysed decomposition of GSNO, thus, nitric oxide was released. Conclusion. MT could markedly d

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Studium obranných mechanismů rostlin při stresu způsobeném těžkými kovy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical chemistry

ISSN

0009-9147

e-ISSN

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Svazek periodika

52

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

1

Strana od-do

"A175"-"A175"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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