Lead ions encapsulated in liposomes and their effect on Staphylococcus aureus
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F13%3A00213005" target="_blank" >RIV/62156489:43210/13:00213005 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62157124:16270/13:43872367
Výsledek na webu
<a href="http://dx.doi.org/10.3390/ijerph10126687" target="_blank" >http://dx.doi.org/10.3390/ijerph10126687</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijerph10126687" target="_blank" >10.3390/ijerph10126687</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Lead ions encapsulated in liposomes and their effect on Staphylococcus aureus
Popis výsledku v původním jazyce
The aim of the study was the preparation of a liposome complex with encapsulated lead ions, which were electrochemically detected. In particular, experiments were focused on the potential of using an electrochemical method for the determination of free and liposome-encapsulated lead and determination of the encapsulation efficiency preventing the lead toxicity. Primarily, encapsulation of lead ions in liposomes and confirmation of successful encapsulation by electrochemical methods was done. Further, the reduction effect of the liposome matrix on the detected electrochemical signal was monitored. Besides encapsulation itself, comparison of toxicity of free lead ions and lead ions encapsulated in liposome was tested. The calculated IC50 values for evaluating the lead cytotoxicity showed significant differences between the lead enclosed in liposomes (28 uM) and free lead ions (237 uM). From the cytotoxicity studies on the bacterial strain of S. aureus it was observed that the free lead i
Název v anglickém jazyce
Lead ions encapsulated in liposomes and their effect on Staphylococcus aureus
Popis výsledku anglicky
The aim of the study was the preparation of a liposome complex with encapsulated lead ions, which were electrochemically detected. In particular, experiments were focused on the potential of using an electrochemical method for the determination of free and liposome-encapsulated lead and determination of the encapsulation efficiency preventing the lead toxicity. Primarily, encapsulation of lead ions in liposomes and confirmation of successful encapsulation by electrochemical methods was done. Further, the reduction effect of the liposome matrix on the detected electrochemical signal was monitored. Besides encapsulation itself, comparison of toxicity of free lead ions and lead ions encapsulated in liposome was tested. The calculated IC50 values for evaluating the lead cytotoxicity showed significant differences between the lead enclosed in liposomes (28 uM) and free lead ions (237 uM). From the cytotoxicity studies on the bacterial strain of S. aureus it was observed that the free lead i
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EE - Mikrobiologie, virologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>
Návaznosti
O - Projekt operacniho programu
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Environmental Research and Public Health
ISSN
1660-4601
e-ISSN
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Svazek periodika
10
Číslo periodika v rámci svazku
12
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
14
Strana od-do
6687-6700
Kód UT WoS článku
330219600026
EID výsledku v databázi Scopus
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