The influence of polyunsaturated fatty acids on cholesterol homeostasis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F13%3A43908840" target="_blank" >RIV/62156489:43210/13:43908840 - isvavai.cz</a>

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2013/mnet_2013_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2013/mnet_2013_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The influence of polyunsaturated fatty acids on cholesterol homeostasis

Popis výsledku v původním jazyce

The aim of this work was to validate the hypothesis of a positive influence of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) on the proportion of plasmatic lipids. These polyunsaturated fatty acids can decrease the plasma cholesterol due tothe increase in expression of the gene Insig-1 together with the decrease in expression of the genes coding HMG-CoA-R and LDL-R. Hypothesis had been tested on experimental animals (Rattus norvegicus) that were fed with a standard feeding mixture, with the addition of 3 % fish oil (salmon oil). The expression of the gene Insig-1 in animals livers that had been fed with the feed with the additon of salmon oil was 730 % (P < 0.05) compared to the control. However, on the contrary to the hypothesis, the expression of the gene HMG-CoA-R was 165 % (P > 0.05) and the expression of the gene for LDL-R was 210 % (P > 0.05) compared to the control. Nevertheless, it was proved (P < 0.05) that the fish oil used for the diet of the experimental rats

Název v anglickém jazyce

The influence of polyunsaturated fatty acids on cholesterol homeostasis

Popis výsledku anglicky

The aim of this work was to validate the hypothesis of a positive influence of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) on the proportion of plasmatic lipids. These polyunsaturated fatty acids can decrease the plasma cholesterol due tothe increase in expression of the gene Insig-1 together with the decrease in expression of the genes coding HMG-CoA-R and LDL-R. Hypothesis had been tested on experimental animals (Rattus norvegicus) that were fed with a standard feeding mixture, with the addition of 3 % fish oil (salmon oil). The expression of the gene Insig-1 in animals livers that had been fed with the feed with the additon of salmon oil was 730 % (P < 0.05) compared to the control. However, on the contrary to the hypothesis, the expression of the gene HMG-CoA-R was 165 % (P > 0.05) and the expression of the gene for LDL-R was 210 % (P > 0.05) compared to the control. Nevertheless, it was proved (P < 0.05) that the fish oil used for the diet of the experimental rats

Druh

D - Stať ve sborníku

CEP obor

GM - Potravinářství

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2013: Proceedings of International PhD Students Conference

ISBN

978-80-7375-908-7

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

621-625

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

20. 11. 2013

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000366464800107