Synthesis of PLGA nanoparticles with entrapped antibiotic mupirocin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919624" target="_blank" >RIV/62156489:43210/20:43919624 - isvavai.cz</a>

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of PLGA nanoparticles with entrapped antibiotic mupirocin

Popis výsledku v původním jazyce

Infections caused by resistant strains of bacteria have reached a critical level calling for increasingly effective delivery system of drugs to prevent and treat these infections. PLGA nanoparticles (NP) with mupirocin encapsulated could be good for better and quicker wound healing process. The aim of the experiment is to develop PLGA NPs with entrapped mupirocin and determine basic characteristic of it. Mupirocin is effective antibiotic in the fight against mentioned infection. For synthesis of these NPs was used emulsion evaporation method. Characterization of prepared NPs consisted of measuring size (141.1 +- 9.3 nm), zeta potential (-21.9 +- 4.6 mV) and morphology by method TEM. Also, we did a release profile of mupirocin from NPs. Loading capacity was calculated as 2.34 μg and entrapped efficiency as 22.4%.

Název v anglickém jazyce

Synthesis of PLGA nanoparticles with entrapped antibiotic mupirocin

Popis výsledku anglicky

Infections caused by resistant strains of bacteria have reached a critical level calling for increasingly effective delivery system of drugs to prevent and treat these infections. PLGA nanoparticles (NP) with mupirocin encapsulated could be good for better and quicker wound healing process. The aim of the experiment is to develop PLGA NPs with entrapped mupirocin and determine basic characteristic of it. Mupirocin is effective antibiotic in the fight against mentioned infection. For synthesis of these NPs was used emulsion evaporation method. Characterization of prepared NPs consisted of measuring size (141.1 +- 9.3 nm), zeta potential (-21.9 +- 4.6 mV) and morphology by method TEM. Also, we did a release profile of mupirocin from NPs. Loading capacity was calculated as 2.34 μg and entrapped efficiency as 22.4%.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2020: Proceedings of International PhD Students Conference

ISBN

978-80-7509-765-1

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

589-593

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

11. 11. 2020

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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