Antimicrobial activity of PLGA nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919601" target="_blank" >RIV/62156489:43210/20:43919601 - isvavai.cz</a>

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antimicrobial activity of PLGA nanoparticles

Popis výsledku v původním jazyce

Nowadays, one of the major problems in the world is occurring antimicrobial resistance of bacteria. Nanoencapsulation offers great potential in overcoming of antibiotics resistance using natural compounds for delivery. PLGA nanoparticles with entrapped mupirocin and fish oil have promising potential for nanodelivery system. Mupirocin is effective in inhibition of major grampositive bacteria. Fish oil has anti-inflammatory and regenerating effects in the healing process of the skin due to the content of long-chain n-3 polyunsaturated fatty acids (PUFAs). Expectedly, no antimicrobial effect was observed by PLGA with encapsulated fish oil unlike PLGA with encapsulated mupirocin. Unfortunately, the antimicrobial activity of mupirocin alone was significant compared to encapsulated mupirocin. Despite the following results, PLGA nanoparticles should be further studied and their production improved for other purposes.

Název v anglickém jazyce

Antimicrobial activity of PLGA nanoparticles

Popis výsledku anglicky

Nowadays, one of the major problems in the world is occurring antimicrobial resistance of bacteria. Nanoencapsulation offers great potential in overcoming of antibiotics resistance using natural compounds for delivery. PLGA nanoparticles with entrapped mupirocin and fish oil have promising potential for nanodelivery system. Mupirocin is effective in inhibition of major grampositive bacteria. Fish oil has anti-inflammatory and regenerating effects in the healing process of the skin due to the content of long-chain n-3 polyunsaturated fatty acids (PUFAs). Expectedly, no antimicrobial effect was observed by PLGA with encapsulated fish oil unlike PLGA with encapsulated mupirocin. Unfortunately, the antimicrobial activity of mupirocin alone was significant compared to encapsulated mupirocin. Despite the following results, PLGA nanoparticles should be further studied and their production improved for other purposes.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10606 - Microbiology

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2020: Proceedings of International PhD Students Conference

ISBN

978-80-7509-765-1

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

517-521

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

11. 11. 2020

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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