Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F01%3A00000745" target="_blank" >RIV/62157124:16170/01:00000745 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio

Popis výsledku v původním jazyce

: The aim of this work was to evaluate the response of dogs with pituitary-dependent hyperadrenocorticism to treatment with mitotane. The relationship between duration of initial phase of therapy and the initial value of urine cortisol/creatinine ratio(UCCR) was studied. All 14 dogs with pituitary-dependent hyperadrenocorticism were treated. Therapeutic protocol of selective adrenocorticolysis was used. The induction dose of mitotane was 25 mg/kg daily. The length of initial phase of therapy was dete rmined individually on the basis of cortisol production changes, which were monitored by immunoreactive cortisol in urine (UCCR) every 2 - 5 days during the initial phase of treatment. High-dose dexamethasone suppression test was used to differentiate between the pituitary-dependent and adrenal-dependent form of the disease, and the UCCR was measured after dexamethasone suppression. The value of the initial UCCR fluctuated between 58-586 x 10-6 , the median of UCCR was 138 x 10-6 . Initial

Název v anglickém jazyce

Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio

Popis výsledku anglicky

: The aim of this work was to evaluate the response of dogs with pituitary-dependent hyperadrenocorticism to treatment with mitotane. The relationship between duration of initial phase of therapy and the initial value of urine cortisol/creatinine ratio(UCCR) was studied. All 14 dogs with pituitary-dependent hyperadrenocorticism were treated. Therapeutic protocol of selective adrenocorticolysis was used. The induction dose of mitotane was 25 mg/kg daily. The length of initial phase of therapy was dete rmined individually on the basis of cortisol production changes, which were monitored by immunoreactive cortisol in urine (UCCR) every 2 - 5 days during the initial phase of treatment. High-dose dexamethasone suppression test was used to differentiate between the pituitary-dependent and adrenal-dependent form of the disease, and the UCCR was measured after dexamethasone suppression. The value of the initial UCCR fluctuated between 58-586 x 10-6 , the median of UCCR was 138 x 10-6 . Initial

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria

ISSN

0001-7213

e-ISSN

—

Svazek periodika

70

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

313-320

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—