Antimycobacterial and herbicidal activity of ring-substituted 1-hydroxynaphthalene-2-carboxanilides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F13%3A43871896" target="_blank" >RIV/62157124:16170/13:43871896 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/13:43871896

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bmc.2013.08.030" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2013.08.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2013.08.030" target="_blank" >10.1016/j.bmc.2013.08.030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antimycobacterial and herbicidal activity of ring-substituted 1-hydroxynaphthalene-2-carboxanilides

Popis výsledku v původním jazyce

In this study, a series of 22 ring-substituted 1-hydroxynaphthalene-2-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Mycobacterium marinum, Mycobacterium kansasii and Mycobacterium smegmatis. The compounds were also tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Most of tested compounds showed the antimycobacterial activity against thethree strains comparable or higher than the standard isoniazid. N-(3-Fluorophenyl)-1-hydroxynaphthalene-2-carboxamide showed the highest biological activity (MIC = 28.4 mu mol/L) against M. marinum, N-(4-fluorophenyl)-1-hydroxynaphthalene-2-carboxamideshowed the highest biological activity (MIC = 14.2 mu pi mol/L) against M. kansasii, and N-(4-bromophenyl)-1-hydroxynaphthalene-2-carboxamide expressed the highest biological activity (MIC = 46.7 mu mol/L) against M. smegmatis. This compo

Název v anglickém jazyce

Antimycobacterial and herbicidal activity of ring-substituted 1-hydroxynaphthalene-2-carboxanilides

Popis výsledku anglicky

In this study, a series of 22 ring-substituted 1-hydroxynaphthalene-2-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Mycobacterium marinum, Mycobacterium kansasii and Mycobacterium smegmatis. The compounds were also tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Most of tested compounds showed the antimycobacterial activity against thethree strains comparable or higher than the standard isoniazid. N-(3-Fluorophenyl)-1-hydroxynaphthalene-2-carboxamide showed the highest biological activity (MIC = 28.4 mu mol/L) against M. marinum, N-(4-fluorophenyl)-1-hydroxynaphthalene-2-carboxamideshowed the highest biological activity (MIC = 14.2 mu pi mol/L) against M. kansasii, and N-(4-bromophenyl)-1-hydroxynaphthalene-2-carboxamide expressed the highest biological activity (MIC = 46.7 mu mol/L) against M. smegmatis. This compo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bioorganic and Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

6531-6541

Kód UT WoS článku

000325164500028

EID výsledku v databázi Scopus

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