Investigation of Pathological Haemorrhage in Maine Coon Cats

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Investigation of Pathological Haemorrhage in Maine Coon Cats

Popis výsledku v původním jazyce

Afibrinogenaemic haemorrhage was previously reported in a Maine Coon cat. Two littermates subsequently died from surgical non-haemostasis, suggesting at a hereditable coagulopathy. Methods: We prospectively recruited cats which were; a) Maine Coons with pathological haemorrhage (Group 1, n=8) b) healthy familial relatives of Group 1 (Group 2, n=13) and c) healthy Maine Coons unrelated to Groups 1 and 2 (Group 3, n=12). Cats were convenience blood-sampled and coagulation tests; prothrombin time, activated partial thromboplastin time and thrombin clotting time (TCT) were performed on citrated plasma along with quantification of fibrinogen. Routine haematological examination was performed on EDTA-anticoagulated blood collected contemporaneously. Results: Thirty-three blood samples were analysed. Fibrinogen concentrations were significantly reduced in Groups 1 (p&lt;0.01) and 2 (p&lt;0.01) compared to Group 3. Similarly, TCT was found to be significantly extended in Group 1 (p&lt;0.01) and Group 2 (p=0.02) with respect to Group 3. Conclusions and relevance: Dysfibrinogenaemia was identified in clinical cases and their healthy relatives, supporting the hypothesis that this is a hereditary condition of Maine Coon cats. Clinicians should be aware of the increased potential

Název v anglickém jazyce

Investigation of Pathological Haemorrhage in Maine Coon Cats

Popis výsledku anglicky

Afibrinogenaemic haemorrhage was previously reported in a Maine Coon cat. Two littermates subsequently died from surgical non-haemostasis, suggesting at a hereditable coagulopathy. Methods: We prospectively recruited cats which were; a) Maine Coons with pathological haemorrhage (Group 1, n=8) b) healthy familial relatives of Group 1 (Group 2, n=13) and c) healthy Maine Coons unrelated to Groups 1 and 2 (Group 3, n=12). Cats were convenience blood-sampled and coagulation tests; prothrombin time, activated partial thromboplastin time and thrombin clotting time (TCT) were performed on citrated plasma along with quantification of fibrinogen. Routine haematological examination was performed on EDTA-anticoagulated blood collected contemporaneously. Results: Thirty-three blood samples were analysed. Fibrinogen concentrations were significantly reduced in Groups 1 (p&lt;0.01) and 2 (p&lt;0.01) compared to Group 3. Similarly, TCT was found to be significantly extended in Group 1 (p&lt;0.01) and Group 2 (p=0.02) with respect to Group 3. Conclusions and relevance: Dysfibrinogenaemia was identified in clinical cases and their healthy relatives, supporting the hypothesis that this is a hereditary condition of Maine Coon cats. Clinicians should be aware of the increased potential

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů