Investigation of pathological haemorrhage in Maine Coon cats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F20%3A43878474" target="_blank" >RIV/62157124:16170/20:43878474 - isvavai.cz</a>

Výsledek na webu

<a href="https://bvajournals.onlinelibrary.wiley.com/journal/20427670" target="_blank" >https://bvajournals.onlinelibrary.wiley.com/journal/20427670</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/vr.105503" target="_blank" >10.1136/vr.105503</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Investigation of pathological haemorrhage in Maine Coon cats

Popis výsledku v původním jazyce

Objective Afibrinogenaemic haemorrhage was previously reported in a Maine Coon cat. Two littermates subsequently died from surgical non-haemostasis, suggesting a hereditable coagulopathy. Methods We prospectively recruited cats which were: a) Maine Coons with pathological haemorrhage (group 1, n=8), b) healthy familial relatives of group 1 (group 2, n=13) and c) healthy Maine Coons unrelated to groups 1 and 2 (group 3, n=12). Coagulation tests: prothrombin time, activated partial thromboplastin time and thrombin clotting time (TCT) were performed on citrated plasma along with quantification of fibrinogen. Routine haematological examination was performed on EDTA-anticoagulated blood collected contemporaneously. Results Thirty-three blood samples were analysed. Fibrinogen concentrations were significantly reduced in groups 1 (P&lt;0.01) and 2 (P&lt;0.01) compared with group 3. Similarly, TCT was found to be significantly extended in group 1 (P&lt;0.01) and group 2 (P=0.02) with respect to group 3. Conclusions Dysfibrinogenaemia was identified in clinical cases and their healthy relatives, suggesting that this may represent a hereditary condition of Maine Coon cats. Clinicians should be aware of the increased potential for non-haemostasis in this cat breed and consider assessing clotting function before (elective) surgery.

Název v anglickém jazyce

Investigation of pathological haemorrhage in Maine Coon cats

Popis výsledku anglicky

Objective Afibrinogenaemic haemorrhage was previously reported in a Maine Coon cat. Two littermates subsequently died from surgical non-haemostasis, suggesting a hereditable coagulopathy. Methods We prospectively recruited cats which were: a) Maine Coons with pathological haemorrhage (group 1, n=8), b) healthy familial relatives of group 1 (group 2, n=13) and c) healthy Maine Coons unrelated to groups 1 and 2 (group 3, n=12). Coagulation tests: prothrombin time, activated partial thromboplastin time and thrombin clotting time (TCT) were performed on citrated plasma along with quantification of fibrinogen. Routine haematological examination was performed on EDTA-anticoagulated blood collected contemporaneously. Results Thirty-three blood samples were analysed. Fibrinogen concentrations were significantly reduced in groups 1 (P&lt;0.01) and 2 (P&lt;0.01) compared with group 3. Similarly, TCT was found to be significantly extended in group 1 (P&lt;0.01) and group 2 (P=0.02) with respect to group 3. Conclusions Dysfibrinogenaemia was identified in clinical cases and their healthy relatives, suggesting that this may represent a hereditary condition of Maine Coon cats. Clinicians should be aware of the increased potential for non-haemostasis in this cat breed and consider assessing clotting function before (elective) surgery.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Record

ISSN

0042-4900

e-ISSN

—

Svazek periodika

187

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

17

Strana od-do

1-16

Kód UT WoS článku

000608475200012

EID výsledku v databázi Scopus

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