Study of deoxynivalenol effect on metallothionein and glutathione levels, antioxidant capacity, and glutathione-S-transferase and liver enzymes activity in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F12%3A43871396" target="_blank" >RIV/62157124:16270/12:43871396 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/12:00194045 RIV/00216305:26620/12:PU100803

Výsledek na webu

<a href="http://web2.mendelu.cz/af_239_nanotech/data/pub/138-12_Sobrova_author.pdf" target="_blank" >http://web2.mendelu.cz/af_239_nanotech/data/pub/138-12_Sobrova_author.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11696-012-0229-0" target="_blank" >10.2478/s11696-012-0229-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Study of deoxynivalenol effect on metallothionein and glutathione levels, antioxidant capacity, and glutathione-S-transferase and liver enzymes activity in rats

Popis výsledku v původním jazyce

Deoxynivalenol (DON, vomitoxin) is one of several human mycotoxins acquired through residues in foods of plant origin (cereals) and through foods of animal origin (kidneys, liver, milk, eggs). The aim of this study was to investigate the impact of deoxynivalenol-contaminated mouldy grain on the health status of rats and their ability to resist oxidative stress. The rats were fed a diet supplemented with DON along with organic and inorganic Zn(II), and vitamins for 28 days. The study focuses particularlyon protective mechanisms and levels of reduced glutathione and metallothioneins (MT) against the adverse effects of xenobiotics. The highest concentrations of MT were detected in the tissues of kidneys ((6.70 +- 0.05) mýg g?1) and liver ((6.00 +- 0.05)mýg g?1), both of which are involved in detoxifying cationic xenobiotics. Lower concentrations were also detected in heart, brain, testes, and muscle tissues (approximately 3.0 mýg g?1). Antioxidant capacity, glutathione-S-transferase, an

Název v anglickém jazyce

Study of deoxynivalenol effect on metallothionein and glutathione levels, antioxidant capacity, and glutathione-S-transferase and liver enzymes activity in rats

Popis výsledku anglicky

Deoxynivalenol (DON, vomitoxin) is one of several human mycotoxins acquired through residues in foods of plant origin (cereals) and through foods of animal origin (kidneys, liver, milk, eggs). The aim of this study was to investigate the impact of deoxynivalenol-contaminated mouldy grain on the health status of rats and their ability to resist oxidative stress. The rats were fed a diet supplemented with DON along with organic and inorganic Zn(II), and vitamins for 28 days. The study focuses particularlyon protective mechanisms and levels of reduced glutathione and metallothioneins (MT) against the adverse effects of xenobiotics. The highest concentrations of MT were detected in the tissues of kidneys ((6.70 +- 0.05) mýg g?1) and liver ((6.00 +- 0.05)mýg g?1), both of which are involved in detoxifying cationic xenobiotics. Lower concentrations were also detected in heart, brain, testes, and muscle tissues (approximately 3.0 mýg g?1). Antioxidant capacity, glutathione-S-transferase, an

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Papers - Chemické Zvesti

ISSN

0366-6352

e-ISSN

—

Svazek periodika

66

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

11

Strana od-do

1092-1102

Kód UT WoS článku

000308649300002

EID výsledku v databázi Scopus

—