Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870661" target="_blank" >RIV/62157124:16370/11:43870661 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.intimp.2011.02.016" target="_blank" >http://dx.doi.org/10.1016/j.intimp.2011.02.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.intimp.2011.02.016" target="_blank" >10.1016/j.intimp.2011.02.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells

Popis výsledku v původním jazyce

The cytotoxicity and in vitro effects of six variously modified types of cellulose (OC - oxidized cellulose, NaOC - oxidized cellulose sodium salt, DAC - dialdehyde cellulose, CMC - carboxymethyl cellulose, MFC - microfibrilated cellulose, and MCC - microcrystalline cellulose) on the inflammatory response in macrophage-like THP-1 cells were examined, with special focus on their ability to influence gene expression and the production of TNF-alpha. The study provides evidence that DAC exerts a marked effect on the induction of TNF-alpha gene expression and its subsequent production in human macrophages. Thus, the use of DAC for anti-hemorrhagic or wound-healing therapy should be considered carefully with regard to its pro-inflammatory activity. On the contrary, MCC showed significant anti-inflammatory effects in the LPS-induced conditions, which might be beneficial for the treatment of non-healing chronic wounds, e.g., diabetic or venous ulcers.

Název v anglickém jazyce

Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells

Popis výsledku anglicky

The cytotoxicity and in vitro effects of six variously modified types of cellulose (OC - oxidized cellulose, NaOC - oxidized cellulose sodium salt, DAC - dialdehyde cellulose, CMC - carboxymethyl cellulose, MFC - microfibrilated cellulose, and MCC - microcrystalline cellulose) on the inflammatory response in macrophage-like THP-1 cells were examined, with special focus on their ability to influence gene expression and the production of TNF-alpha. The study provides evidence that DAC exerts a marked effect on the induction of TNF-alpha gene expression and its subsequent production in human macrophages. Thus, the use of DAC for anti-hemorrhagic or wound-healing therapy should be considered carefully with regard to its pro-inflammatory activity. On the contrary, MCC showed significant anti-inflammatory effects in the LPS-induced conditions, which might be beneficial for the treatment of non-healing chronic wounds, e.g., diabetic or venous ulcers.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/2A-1TP1%2F073" target="_blank" >2A-1TP1/073: *Nové farmaceutické produkty na bázi polysacharidů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL IMMUNOPHARMACOLOGY

ISSN

1567-5769

e-ISSN

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Svazek periodika

11

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

997-1001

Kód UT WoS článku

000293723400014

EID výsledku v databázi Scopus

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