Study of stability of potential beta-adrenolytics, derivatives of the [(arylcarbonyl)oxy]aminopropanol by kinetics of alkaline hydrolysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870772" target="_blank" >RIV/62157124:16370/11:43870772 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2478/v10219-011-0008-y" target="_blank" >http://dx.doi.org/10.2478/v10219-011-0008-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10219-011-0008-y" target="_blank" >10.2478/v10219-011-0008-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Study of stability of potential beta-adrenolytics, derivatives of the [(arylcarbonyl)oxy]aminopropanol by kinetics of alkaline hydrolysis

Popis výsledku v původním jazyce

This work deals with the study of the stability of six derivatives of the [(arylcarbonyl)oxy]amino propanol with carbamate substitution on the benzene ring. The studied compounds are different in the substitution on the amine group in the side chain as well as in the substitution on the carbamate functional group. The hydrolysis of compounds was measured in the aqueous-ethanol sodium hydroxide solution (0.1 mol.l-1) at 25, 37, 45 and 60 °C spectrophotometrically in the ultraviolet and visual regions. The studied compounds possess two functional groups, which undergo hydrolysis. The pseudo-first order rate constants of hydrolysis for individual reaction steps were determined. The ester functional group of compounds hydrolyses very quickly in this medium. The compounds possessing the tertiary substitution on the amino group are less stable toward alkaline hydrolysis. The course of hydrolysis of compounds was also investigated by thin layer chromatography (TLC).

Název v anglickém jazyce

Study of stability of potential beta-adrenolytics, derivatives of the [(arylcarbonyl)oxy]aminopropanol by kinetics of alkaline hydrolysis

Popis výsledku anglicky

This work deals with the study of the stability of six derivatives of the [(arylcarbonyl)oxy]amino propanol with carbamate substitution on the benzene ring. The studied compounds are different in the substitution on the amine group in the side chain as well as in the substitution on the carbamate functional group. The hydrolysis of compounds was measured in the aqueous-ethanol sodium hydroxide solution (0.1 mol.l-1) at 25, 37, 45 and 60 °C spectrophotometrically in the ultraviolet and visual regions. The studied compounds possess two functional groups, which undergo hydrolysis. The pseudo-first order rate constants of hydrolysis for individual reaction steps were determined. The ester functional group of compounds hydrolyses very quickly in this medium. The compounds possessing the tertiary substitution on the amino group are less stable toward alkaline hydrolysis. The course of hydrolysis of compounds was also investigated by thin layer chromatography (TLC).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Facultatis Pharmaceuticae Universitatis Comenianae Bratislava

ISSN

0301-2298

e-ISSN

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Svazek periodika

58

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

9

Strana od-do

72-80

Kód UT WoS článku

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EID výsledku v databázi Scopus

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