Relationship between chemical structure, binding affinity and selectivity towards alfa1-adrenoceptors in the group of substituted n-phenylpiperazines. Part 2*. compounds containing ethane-1,2-diyl connecting chain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870898" target="_blank" >RIV/62157124:16370/11:43870898 - isvavai.cz</a>

Výsledek na webu

<a href="http://versita.metapress.com/content/l465316n7362w6l0/fulltext.pdf" target="_blank" >http://versita.metapress.com/content/l465316n7362w6l0/fulltext.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10219-011-0005-1" target="_blank" >10.2478/v10219-011-0005-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Relationship between chemical structure, binding affinity and selectivity towards alfa1-adrenoceptors in the group of substituted n-phenylpiperazines. Part 2*. compounds containing ethane-1,2-diyl connecting chain

Popis výsledku v původním jazyce

The N-phenylpiperazine structures exhibit very extensive multiple receptor activities including the influencing of alfa1-adrenoceptors (alfa1-AR). Their antagonistic activity towards alfa1-AR is intensively applied in the therapy of cardiovascular systemdiseases - e. g. hypertension as well as in the treatment of benign prostatic hyperplasia. The limited ratio of selective effect on the specific subtypes of the alfa1-AR by certain drugs used in the practice (azosine-type structures) leads to multiple side effects which includes postural hypotension, syncope or first dose phenomena. The existence of multiple alfa1-AR subtypes holds promise for the discovery, projection and development of more specific selective drug molecules targeting only one alfa1-adrenoceptor subtype and making them free from side effects. Towards this aim wide-ranging modifications have been reported in the literature on the "basic" structure of the N-phenylpiperazine-based molecules. The present paper deals with

Název v anglickém jazyce

Relationship between chemical structure, binding affinity and selectivity towards alfa1-adrenoceptors in the group of substituted n-phenylpiperazines. Part 2*. compounds containing ethane-1,2-diyl connecting chain

Popis výsledku anglicky

The N-phenylpiperazine structures exhibit very extensive multiple receptor activities including the influencing of alfa1-adrenoceptors (alfa1-AR). Their antagonistic activity towards alfa1-AR is intensively applied in the therapy of cardiovascular systemdiseases - e. g. hypertension as well as in the treatment of benign prostatic hyperplasia. The limited ratio of selective effect on the specific subtypes of the alfa1-AR by certain drugs used in the practice (azosine-type structures) leads to multiple side effects which includes postural hypotension, syncope or first dose phenomena. The existence of multiple alfa1-AR subtypes holds promise for the discovery, projection and development of more specific selective drug molecules targeting only one alfa1-adrenoceptor subtype and making them free from side effects. Towards this aim wide-ranging modifications have been reported in the literature on the "basic" structure of the N-phenylpiperazine-based molecules. The present paper deals with

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Facultatis Pharmaceuticae Universitatis Comenianae Bratislava

ISSN

0301-2298

e-ISSN

—

Svazek periodika

58

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

14

Strana od-do

42-55

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—