Contribution to antimicrobial profile investigation of phenylcarbamic acid derivatives containing substituted N-phenylpiperazine fragment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871063" target="_blank" >RIV/62157124:16370/12:43871063 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Contribution to antimicrobial profile investigation of phenylcarbamic acid derivatives containing substituted N-phenylpiperazine fragment

Popis výsledku v původním jazyce

The set of new original, higly lipophilic basic esters of phenylcarbamic acid containing 4-(2-fluoro-/4-fluorophenyl)piperazin-1-yl moiety, labelled as 1-12, was screened for in vitro antimicrobial activity against Escherichia coli, Candida albicans andStaphylococcus aureus, respectively. Following the minimum inhibitory concentration (MIC) assay by microdilution method, all tested molecules were against S. aureus, E. coli as well as C. albicans practically inactive. The study has revealed that the position of carbamate group have appeared to be the most notable factor which decisively influence the activity of tested compounds in the comparison with the importance of electronic or hydrophobic interactions induced by the substitution at the N-phenylpiperazine ring. Additionally, the lipophilicity rising had been regarded as relevant but not ultimate aspect for the effectiveness of these molecules. Finally it can be concluded that mandatory requirement for the activity maintenance agai

Název v anglickém jazyce

Contribution to antimicrobial profile investigation of phenylcarbamic acid derivatives containing substituted N-phenylpiperazine fragment

Popis výsledku anglicky

The set of new original, higly lipophilic basic esters of phenylcarbamic acid containing 4-(2-fluoro-/4-fluorophenyl)piperazin-1-yl moiety, labelled as 1-12, was screened for in vitro antimicrobial activity against Escherichia coli, Candida albicans andStaphylococcus aureus, respectively. Following the minimum inhibitory concentration (MIC) assay by microdilution method, all tested molecules were against S. aureus, E. coli as well as C. albicans practically inactive. The study has revealed that the position of carbamate group have appeared to be the most notable factor which decisively influence the activity of tested compounds in the comparison with the importance of electronic or hydrophobic interactions induced by the substitution at the N-phenylpiperazine ring. Additionally, the lipophilicity rising had been regarded as relevant but not ultimate aspect for the effectiveness of these molecules. Finally it can be concluded that mandatory requirement for the activity maintenance agai

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Biological and Medical Research

ISSN

0976-6685

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

2531-2534

Kód UT WoS článku

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EID výsledku v databázi Scopus

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