Antimicrobial profile investigation of novel prospective ultra-short acting antagonists of beta-adrenergic receptors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43872704" target="_blank" >RIV/62157124:16370/14:43872704 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antimicrobial profile investigation of novel prospective ultra-short acting antagonists of beta-adrenergic receptors

Popis výsledku v původním jazyce

Due to Worldwide phenomenon of microbial résistance to commonly used therapeutic agents, antibiotics and antifungals as well, a non-traditional séries of perspective ultra-short acting beta-adrenoceptor blockers, labelled as 1-4, has been in vitro evaluated against selected Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial strains as well as against yeast (C. albicans) by the minimum inhibitory concentration (MIC) assay. From chemical viewpoint, the présence of polar carboxy group within the structure of tested compounds has not found to be favourable structural feature because of its supposed splitting by the enzymes which have been produced by ail concerned microorganisms. On the other hand, within inspected set ofthe compounds, the increase in the lipophilicity has meant moderate improvement of the effectiveness against S. aureus and C. albicans, reaching the maximum for the most lipophilic substance 4 which has shown MIC=0.78 mg?mL-1 for given ba

Název v anglickém jazyce

Antimicrobial profile investigation of novel prospective ultra-short acting antagonists of beta-adrenergic receptors

Popis výsledku anglicky

Due to Worldwide phenomenon of microbial résistance to commonly used therapeutic agents, antibiotics and antifungals as well, a non-traditional séries of perspective ultra-short acting beta-adrenoceptor blockers, labelled as 1-4, has been in vitro evaluated against selected Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial strains as well as against yeast (C. albicans) by the minimum inhibitory concentration (MIC) assay. From chemical viewpoint, the présence of polar carboxy group within the structure of tested compounds has not found to be favourable structural feature because of its supposed splitting by the enzymes which have been produced by ail concerned microorganisms. On the other hand, within inspected set ofthe compounds, the increase in the lipophilicity has meant moderate improvement of the effectiveness against S. aureus and C. albicans, reaching the maximum for the most lipophilic substance 4 which has shown MIC=0.78 mg?mL-1 for given ba

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Asian Journal of Microbiology, Biotechnology and Environmental Sciences

ISSN

0972-3005

e-ISSN

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Svazek periodika

16

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

6

Strana od-do

1-5

Kód UT WoS článku

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EID výsledku v databázi Scopus

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