STRUCTURE-ANTIMICROBIAL PROPERTIES STUDY OF SOME DIBASIC PHENYLCARBAMIC ACID ESTERS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F16%3A43874622" target="_blank" >RIV/62157124:16370/16:43874622 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.14499/indonesianjpharm27iss1pp53" target="_blank" >http://dx.doi.org/10.14499/indonesianjpharm27iss1pp53</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14499/indonesianjpharm27iss1pp53" target="_blank" >10.14499/indonesianjpharm27iss1pp53</a>

Jazyk výsledku

angličtina

Název v původním jazyce

STRUCTURE-ANTIMICROBIAL PROPERTIES STUDY OF SOME DIBASIC PHENYLCARBAMIC ACID ESTERS

Popis výsledku v původním jazyce

Due to worldwide phenomenon of microbial resistance to commonly used therapeutic agents, antibiotics and antifungals, dibasic di-/trimethylphenylcarbamic acid esters 1-3, a non-traditional series of potential antimicrobials, has been in vitro evaluated against chosen gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacterial strains as well as against yeast (C. albicans) by the minimum inhibitory concentration (MIC) assay. Taking into consideration chemical structure of tested derivatives, the incorporation of more than one protonated atom of nitrogen into salt forming fragment positively influenced the activity against E. coli. On the contrary, the presence of one or more methyl groups instead of 3-alkoxy side chain attached to lipophilic aromatic moiety has not found to be favorable structural feature. In entire set of inspected compounds, the most promising results have been found for the compound 3, chemically 1-[3-piperidinium-1-yl-2-({[(2,4,6-trimethylphenyl)amino]carbonyl}oxy)propyl]piperidinium dichloride, against E. coli with the MIC=1.56mg/mL.

Název v anglickém jazyce

STRUCTURE-ANTIMICROBIAL PROPERTIES STUDY OF SOME DIBASIC PHENYLCARBAMIC ACID ESTERS

Popis výsledku anglicky

Due to worldwide phenomenon of microbial resistance to commonly used therapeutic agents, antibiotics and antifungals, dibasic di-/trimethylphenylcarbamic acid esters 1-3, a non-traditional series of potential antimicrobials, has been in vitro evaluated against chosen gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacterial strains as well as against yeast (C. albicans) by the minimum inhibitory concentration (MIC) assay. Taking into consideration chemical structure of tested derivatives, the incorporation of more than one protonated atom of nitrogen into salt forming fragment positively influenced the activity against E. coli. On the contrary, the presence of one or more methyl groups instead of 3-alkoxy side chain attached to lipophilic aromatic moiety has not found to be favorable structural feature. In entire set of inspected compounds, the most promising results have been found for the compound 3, chemically 1-[3-piperidinium-1-yl-2-({[(2,4,6-trimethylphenyl)amino]carbonyl}oxy)propyl]piperidinium dichloride, against E. coli with the MIC=1.56mg/mL.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Indonesian journal of pharmacy

ISSN

2338-9427

e-ISSN

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Svazek periodika

27

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

ID - Indonéská republika

Počet stran výsledku

6

Strana od-do

53-58

Kód UT WoS článku

000378275600008

EID výsledku v databázi Scopus

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