Basic ortho-alkoxyphenylcarbamic acid esters containing variously substituted n-phenyl piperazine fragment and their antimicrobial activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872369" target="_blank" >RIV/62157124:16370/13:43872369 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Basic ortho-alkoxyphenylcarbamic acid esters containing variously substituted n-phenyl piperazine fragment and their antimicrobial activity

Popis výsledku v původním jazyce

Basic esters of ortho-alkoxyphenylcarbamic acid containing 4-(2-fluoro-/4-fluoro-/3-trifluoromethylphenyl)-piperazin-1-yI, 5a-8b, were screened for their in vitro antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus, respectively. Following the minimum inhibitory concentration (MIC) assay, electronic and hydrophobic interactions, induced by suitable substitution at the N-phenylpiperazine ring, have appeared to be more notable factors which positively influenced theefficiency of such compounds against E. coli than the rising of their lipophilicity. Molecules comprising only of single atom of fluorine, 5a-6b, were observed to be more active (MIC=0.39-0.78 mg-mL-1) in the comparison to those with trifluromethyl group (MICs}1.00 mg-mL-1). On the contrary, the lipophilicity increasing of evaluated molecules accompanied by the presence of the substituent at N-phenylpiperazine with electron-withdrawing effect, 8a-8b, has positively reflected in their ef

Název v anglickém jazyce

Basic ortho-alkoxyphenylcarbamic acid esters containing variously substituted n-phenyl piperazine fragment and their antimicrobial activity

Popis výsledku anglicky

Basic esters of ortho-alkoxyphenylcarbamic acid containing 4-(2-fluoro-/4-fluoro-/3-trifluoromethylphenyl)-piperazin-1-yI, 5a-8b, were screened for their in vitro antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus, respectively. Following the minimum inhibitory concentration (MIC) assay, electronic and hydrophobic interactions, induced by suitable substitution at the N-phenylpiperazine ring, have appeared to be more notable factors which positively influenced theefficiency of such compounds against E. coli than the rising of their lipophilicity. Molecules comprising only of single atom of fluorine, 5a-6b, were observed to be more active (MIC=0.39-0.78 mg-mL-1) in the comparison to those with trifluromethyl group (MICs}1.00 mg-mL-1). On the contrary, the lipophilicity increasing of evaluated molecules accompanied by the presence of the substituent at N-phenylpiperazine with electron-withdrawing effect, 8a-8b, has positively reflected in their ef

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fresenius Environmental Bulletin

ISSN

1018-4619

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

5a

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

1603-1608

Kód UT WoS článku

000319179200016

EID výsledku v databázi Scopus

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