The in Vitro Evaluation of ortho-/meta-/para-Alkoxyphenylcarbamic Acid Esters Bearing 4-(2-Fluoro-/2-methylphenyl)piperazin-1-yl Moiety against Mycobacterium tuberculosis H37Ra Strain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873236" target="_blank" >RIV/62157124:16370/14:43873236 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The in Vitro Evaluation of ortho-/meta-/para-Alkoxyphenylcarbamic Acid Esters Bearing 4-(2-Fluoro-/2-methylphenyl)piperazin-1-yl Moiety against Mycobacterium tuberculosis H37Ra Strain

Popis výsledku v původním jazyce

In a continual research of ortho-/meta-/para-alkoxyphenylcarbamic acid esters as antimycobacterially active compounds, the purpose of current paper was to in vitro screen the potency of the molecules containing incorporated substituted N-phenylpiperazin-1-yl moiety against attenuated M. tuberculosis H37Ra strain which was grown in Middlebrook broth, supplemented with Oleic-Albumin-Dextrose- -Catalase supplement and mycobactin J (2 mýg/mL) as well. The susceptibility of concerned mycobacterial strain wasinvestigated in a 96- well plate format, the plates were incubated at 37°C for 7 days. According to minimum inhibitory concentrations, as the lowest concentrations which prevented a visual colour change, it was observed that positional ortho-/meta-/para-alkoxy side chain isomerism as well as high lipophilicity did not decisively influenced the effectiveness of inspected compounds. Moreover, qualitatively different substitution within basic compartment in terms of electronic properties a

Název v anglickém jazyce

The in Vitro Evaluation of ortho-/meta-/para-Alkoxyphenylcarbamic Acid Esters Bearing 4-(2-Fluoro-/2-methylphenyl)piperazin-1-yl Moiety against Mycobacterium tuberculosis H37Ra Strain

Popis výsledku anglicky

In a continual research of ortho-/meta-/para-alkoxyphenylcarbamic acid esters as antimycobacterially active compounds, the purpose of current paper was to in vitro screen the potency of the molecules containing incorporated substituted N-phenylpiperazin-1-yl moiety against attenuated M. tuberculosis H37Ra strain which was grown in Middlebrook broth, supplemented with Oleic-Albumin-Dextrose- -Catalase supplement and mycobactin J (2 mýg/mL) as well. The susceptibility of concerned mycobacterial strain wasinvestigated in a 96- well plate format, the plates were incubated at 37°C for 7 days. According to minimum inhibitory concentrations, as the lowest concentrations which prevented a visual colour change, it was observed that positional ortho-/meta-/para-alkoxy side chain isomerism as well as high lipophilicity did not decisively influenced the effectiveness of inspected compounds. Moreover, qualitatively different substitution within basic compartment in terms of electronic properties a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Microbiology, Biotechnology and Food Sciences

ISSN

1338-5178

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

3

Strana od-do

286-288

Kód UT WoS článku

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EID výsledku v databázi Scopus

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