The in Vitro Evaluation of ortho-/meta-/para-Alkoxyphenylcarbamic Acid Esters Containing Substituted N-Phenylpiperazin-1-yl Fragment against Mycobacterium tuberculosis H37Ra Strain.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873237" target="_blank" >RIV/62157124:16370/14:43873237 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The in Vitro Evaluation of ortho-/meta-/para-Alkoxyphenylcarbamic Acid Esters Containing Substituted N-Phenylpiperazin-1-yl Fragment against Mycobacterium tuberculosis H37Ra Strain.

Popis výsledku v původním jazyce

The purpose of current paper was to in vitro screen the set of ortho-/meta-/para-alkoxyphenylcarbamic acid esters containing 4-(3--trifluoromethylphenyl)piperazin-1-yl moiety for their potency against avirulent Mycobacterium (M.) tuberculosis H37Ra by applying the micromethod for the determination of the minimum inhibitory concentration (MIC). Considered mycobacterial strain was grown in Middlebrook broth, supplemented with Oleic-Albumin-Dextrose-Catalase supplement and mycobactin J (2 mýg/mL) as well.The susceptibility of the strain was investigated in a 96-well plate format, the plates were incubated at 37°C for 7 days. According to estimated MIC readouts it was concluded that para-alkoxy substitution within lipophilic fragment would be favorable for the activity of currently investigated compounds against given mycobacterium. On the other hand, relatively high lipophilicity was not regarded as crucial factor which determined the activity profile of inspected derivatives. Moreover,

Název v anglickém jazyce

The in Vitro Evaluation of ortho-/meta-/para-Alkoxyphenylcarbamic Acid Esters Containing Substituted N-Phenylpiperazin-1-yl Fragment against Mycobacterium tuberculosis H37Ra Strain.

Popis výsledku anglicky

The purpose of current paper was to in vitro screen the set of ortho-/meta-/para-alkoxyphenylcarbamic acid esters containing 4-(3--trifluoromethylphenyl)piperazin-1-yl moiety for their potency against avirulent Mycobacterium (M.) tuberculosis H37Ra by applying the micromethod for the determination of the minimum inhibitory concentration (MIC). Considered mycobacterial strain was grown in Middlebrook broth, supplemented with Oleic-Albumin-Dextrose-Catalase supplement and mycobactin J (2 mýg/mL) as well.The susceptibility of the strain was investigated in a 96-well plate format, the plates were incubated at 37°C for 7 days. According to estimated MIC readouts it was concluded that para-alkoxy substitution within lipophilic fragment would be favorable for the activity of currently investigated compounds against given mycobacterium. On the other hand, relatively high lipophilicity was not regarded as crucial factor which determined the activity profile of inspected derivatives. Moreover,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Microbiology, Biotechnology and Food Sciences

ISSN

1338-5178

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

3

Strana od-do

395-397

Kód UT WoS článku

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EID výsledku v databázi Scopus

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