The development and in vitro evaluation of herbal pellets coated with Eudragit(R) FS 30 D

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873162" target="_blank" >RIV/62157124:16370/15:43873162 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3109/10837450.2014.920355" target="_blank" >http://dx.doi.org/10.3109/10837450.2014.920355</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/10837450.2014.920355" target="_blank" >10.3109/10837450.2014.920355</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The development and in vitro evaluation of herbal pellets coated with Eudragit(R) FS 30 D

Popis výsledku v původním jazyce

The objective of this study was to prepare pellets of thyme (Thymus vulgaris L.), stinging nettle (Urtica dioica L.) and sage (Salvia officinalis L.) dry extracts by extrusion-spheronization technique to improve technological properties and investigate dissolution profiles of pellets covered different levels of pH-sensitive polymer Eudragit(R) FS. Optimal sample of pellets were prepared using microcrystalline cellulose and lactose as excipients and demonstrated excellent technological quality propertiessuch as Hausner ratio (1.07 +- 0.11) and compressibility index (6.73 +- 0.94%) value, spericity (0.87 +- 0.001) and friability (0.22 +- 0.08 N). Pellets were coated by 10-35% (w/w) of Eudragit(R) FS. Dissolution studies showed that less than 20% of coating could not prevent dissolution of phenols in pH 1.2, 20% Eudragit(R) FS coating is enough to prevent herbal extract against dissolution in the stomach. There were observed no statistical significant differences between 20% and 25% or h

Název v anglickém jazyce

The development and in vitro evaluation of herbal pellets coated with Eudragit(R) FS 30 D

Popis výsledku anglicky

The objective of this study was to prepare pellets of thyme (Thymus vulgaris L.), stinging nettle (Urtica dioica L.) and sage (Salvia officinalis L.) dry extracts by extrusion-spheronization technique to improve technological properties and investigate dissolution profiles of pellets covered different levels of pH-sensitive polymer Eudragit(R) FS. Optimal sample of pellets were prepared using microcrystalline cellulose and lactose as excipients and demonstrated excellent technological quality propertiessuch as Hausner ratio (1.07 +- 0.11) and compressibility index (6.73 +- 0.94%) value, spericity (0.87 +- 0.001) and friability (0.22 +- 0.08 N). Pellets were coated by 10-35% (w/w) of Eudragit(R) FS. Dissolution studies showed that less than 20% of coating could not prevent dissolution of phenols in pH 1.2, 20% Eudragit(R) FS coating is enough to prevent herbal extract against dissolution in the stomach. There were observed no statistical significant differences between 20% and 25% or h

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

ISSN

1083-7450

e-ISSN

—

Svazek periodika

20

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

769-774

Kód UT WoS článku

000361337500001

EID výsledku v databázi Scopus

—