Direct Effects of (-)-Epicatechin and Procyanidin B2 on the Respiration of Rat Heart Mitochondria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873529" target="_blank" >RIV/62157124:16370/15:43873529 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2015/232836" target="_blank" >http://dx.doi.org/10.1155/2015/232836</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2015/232836" target="_blank" >10.1155/2015/232836</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Direct Effects of (-)-Epicatechin and Procyanidin B2 on the Respiration of Rat Heart Mitochondria

Popis výsledku v původním jazyce

Flavonol (-)-epicatechin and its derived dimer procyanidin B2, present in high amounts in cocoa products, have been shown to exert beneficial effects on the heart and cardiovascular system; however, their mechanism of action has not been fully elucidated. We studied effects of (-)-epicatechin and procyanidin B2 on the oxidative phosphorylation of isolated rat heart mitochondria. (-)-Epicatechin and procyanidin B2 had stimulating effect (up to 30% compared to control) on substrate-driven (State 2) mitochondrial respiration. Their effect was dependent on the respiratory substrates used. (-)-Epicatechin at higher concentrations (from 0.27 mu g/mL) significantly decreased (up to 15%) substrate-and ADP-driven (State 3) mitochondrial respiration in case of pyruvate and malate oxidation only. Procyanidin B2 (0.7-17.9 ng/mL) inhibited State 3 respiration rate up to 19%, the most profound effect being expressed with succinate as the substrate. (-)-Epicatechin at concentrations of 0.23 mu g/mL a

Název v anglickém jazyce

Direct Effects of (-)-Epicatechin and Procyanidin B2 on the Respiration of Rat Heart Mitochondria

Popis výsledku anglicky

Flavonol (-)-epicatechin and its derived dimer procyanidin B2, present in high amounts in cocoa products, have been shown to exert beneficial effects on the heart and cardiovascular system; however, their mechanism of action has not been fully elucidated. We studied effects of (-)-epicatechin and procyanidin B2 on the oxidative phosphorylation of isolated rat heart mitochondria. (-)-Epicatechin and procyanidin B2 had stimulating effect (up to 30% compared to control) on substrate-driven (State 2) mitochondrial respiration. Their effect was dependent on the respiratory substrates used. (-)-Epicatechin at higher concentrations (from 0.27 mu g/mL) significantly decreased (up to 15%) substrate-and ADP-driven (State 3) mitochondrial respiration in case of pyruvate and malate oxidation only. Procyanidin B2 (0.7-17.9 ng/mL) inhibited State 3 respiration rate up to 19%, the most profound effect being expressed with succinate as the substrate. (-)-Epicatechin at concentrations of 0.23 mu g/mL a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomed Research International

ISSN

2314-6133

e-ISSN

—

Svazek periodika

Neuveden

Číslo periodika v rámci svazku

2015

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

"Nestránkováno"

Kód UT WoS článku

000351098300001

EID výsledku v databázi Scopus

—