Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F16%3A43874496" target="_blank" >RIV/62157124:16370/16:43874496 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00100477

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder

Popis výsledku v původním jazyce

Background/Aim: Autism spectrum disorders (ASD) are complex, and severe heterogeneous neurodevelopmental pathologies with accepted but complex immune system abnormalities. Additional knowledge regarding potential immune dysfunctions may provide a greater understanding of this malady. The aim of this study was to evaluate the CD57(+)CD3(-) mature lymphocyte subpopulation of natural killer cells as a marker of immune dysfunction in ASD. Materials and Methods: Three-color flow cytometry-based analysis of fresh peripheral blood samples from children with autism was utilized to measure CD57(+)CD3(-) lymphocytes. Results. A reduction of CD57(+)CD3(-) lymphocyte count was recorded in a significant number of patients with autism. Discussion and conclusion: We demonstrated that the number of peripheral CD57(+)CD3(-) cells in children with autism often falls below the clinically accepted normal range. This implies that a defect in the counter-regulatory functions necessary for balancing pro-inflammatory cytokines exists, thus opening the way to chronic inflammatory conditions associated with ASD.

Název v anglickém jazyce

Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder

Popis výsledku anglicky

Background/Aim: Autism spectrum disorders (ASD) are complex, and severe heterogeneous neurodevelopmental pathologies with accepted but complex immune system abnormalities. Additional knowledge regarding potential immune dysfunctions may provide a greater understanding of this malady. The aim of this study was to evaluate the CD57(+)CD3(-) mature lymphocyte subpopulation of natural killer cells as a marker of immune dysfunction in ASD. Materials and Methods: Three-color flow cytometry-based analysis of fresh peripheral blood samples from children with autism was utilized to measure CD57(+)CD3(-) lymphocytes. Results. A reduction of CD57(+)CD3(-) lymphocyte count was recorded in a significant number of patients with autism. Discussion and conclusion: We demonstrated that the number of peripheral CD57(+)CD3(-) cells in children with autism often falls below the clinically accepted normal range. This implies that a defect in the counter-regulatory functions necessary for balancing pro-inflammatory cytokines exists, thus opening the way to chronic inflammatory conditions associated with ASD.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

In vivo

ISSN

0258-851X

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

7

Strana od-do

83-89

Kód UT WoS článku

000371066900002

EID výsledku v databázi Scopus

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