Anti-inflammatory Activity of Various Prenylated Phenolic Compounds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876706" target="_blank" >RIV/62157124:16370/18:43876706 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Anti-inflammatory Activity of Various Prenylated Phenolic Compounds

Popis výsledku v původním jazyce

Phenolic compounds can be divided into several categories with the common structural feature of phenolic hydroxyl. Their biological activity is often enhanced by so called prenylation, where the type of the prenyl connection and modification affects the bio-activity. The lecture would shortly summarize the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. Some selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances will be discussed in detail. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation

Název v anglickém jazyce

Anti-inflammatory Activity of Various Prenylated Phenolic Compounds

Popis výsledku anglicky

Phenolic compounds can be divided into several categories with the common structural feature of phenolic hydroxyl. Their biological activity is often enhanced by so called prenylation, where the type of the prenyl connection and modification affects the bio-activity. The lecture would shortly summarize the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. Some selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances will be discussed in detail. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

12th International Symposium on Pharmaceutical Sciences: ISOPS 2018 Proceeding Book

ISBN

978-605-136-408-7

ISSN

—

e-ISSN

neuvedeno

Počet stran výsledku

1

Strana od-do

14

Název nakladatele

ANKARA UNIV PRESS

Místo vydání

Ankara

Místo konání akce

Ankara

Datum konání akce

26. 6. 2018

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

—