Prenylated phenolics with anti-inflammatory effects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877701" target="_blank" >RIV/62157124:16370/19:43877701 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prenylated phenolics with anti-inflammatory effects

Popis výsledku v původním jazyce

The biological activity of phenolics is often modified and enhanced by prenylation by prenyl and geranyl; higher terpenoid chains are rare. The type of the prenyl connection and modification affects their biological activity. The lecture shortly summarizes the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. We would show some of our confirmations of selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation.

Název v anglickém jazyce

Prenylated phenolics with anti-inflammatory effects

Popis výsledku anglicky

The biological activity of phenolics is often modified and enhanced by prenylation by prenyl and geranyl; higher terpenoid chains are rare. The type of the prenyl connection and modification affects their biological activity. The lecture shortly summarizes the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. We would show some of our confirmations of selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10611 - Plant sciences, botany

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů