Prenylated phenolic compounds as potential anti-inflammatory substances

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prenylated phenolic compounds as potential anti-inflammatory substances

Popis výsledku v původním jazyce

Natural phenolics can be divided into different categories with the common structural feature of phenolic hydroxyl. The biological activity of such phenolics is often modified and enhanced by prenylation by prenyl and geranyl; higher terpenoid chains are rare. The type of the prenyl connection and modification affects their biological activity. The lecture would shortly summarize the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. We would show some of our confirmations of selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation.

Název v anglickém jazyce

Prenylated phenolic compounds as potential anti-inflammatory substances

Popis výsledku anglicky

Natural phenolics can be divided into different categories with the common structural feature of phenolic hydroxyl. The biological activity of such phenolics is often modified and enhanced by prenylation by prenyl and geranyl; higher terpenoid chains are rare. The type of the prenyl connection and modification affects their biological activity. The lecture would shortly summarize the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. We would show some of our confirmations of selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Advances in Phytochemical Analysis ? Trends in Natural Products Research

ISBN

978-1-5272-2154-3

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

1

Strana od-do

107

Název nakladatele

Phytochemical Society of Europe

Místo vydání

Cambridge

Místo konání akce

Liverpool

Datum konání akce

2. 7. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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