Anti-inflammatory Activity of Various Phenolics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876832" target="_blank" >RIV/62157124:16370/18:43876832 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Anti-inflammatory Activity of Various Phenolics

Popis výsledku v původním jazyce

Phenolics can be classified into several categories with the common structural moiety of phenolic hydroxyl. Their biological effects are often enhanced by so called prenylation, where the type of the prenyl connection and modification affects the bio-activity. This presentation would briefly summarize the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. Some selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances will be discussed in detail. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation.

Název v anglickém jazyce

Anti-inflammatory Activity of Various Phenolics

Popis výsledku anglicky

Phenolics can be classified into several categories with the common structural moiety of phenolic hydroxyl. Their biological effects are often enhanced by so called prenylation, where the type of the prenyl connection and modification affects the bio-activity. This presentation would briefly summarize the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. Some selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances will be discussed in detail. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů