(Meth)acrylate copolymers of Eudragit? type in oral tablet technology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877756" target="_blank" >RIV/62157124:16370/19:43877756 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2019-5-9/meth-acrylate-copolymers-of-eudragit-type-in-oral-tablet-technology-119280" target="_blank" >https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2019-5-9/meth-acrylate-copolymers-of-eudragit-type-in-oral-tablet-technology-119280</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

(Meth)acrylate copolymers of Eudragit? type in oral tablet technology

Popis výsledku v původním jazyce

This review focuses on the characterization of (meth)acrylate copolymers ? Eudragit?, describing their thermal treatment behaviour, possible interactions between cationic and anionic polymers, incompatibilities related to Eudragits? and their use in the pharmaceutical technology of oral tablets. In summary, Eudragit? copolymers are divided into soluble ones, insoluble ones and a combination of these two types. The combination of soluble and insoluble poly(meth)acrylate gave a new type of polymer, Eudragit? FL. In oral tablet technology, Eudragits? are widely used in matrix tablets, either alone or in combination, where they mainly provide sustained drug release. To a lesser extent, Eudragits? are used in gastroretentive systems. Moreover, Eudragits? are also of great importance in coated tablets technology, where these enteric polymers provide specific drug targeting to certain parts of the digestive tract, mainly to the small intestine or colon. Important systems such as CODESTM and MMX? technology are mentioned. Last but not least an overview table of currently available oral medicinal products on the Czech market, where at least one of the Eudragits? was used as a film-forming agent, is included

Název v anglickém jazyce

(Meth)acrylate copolymers of Eudragit? type in oral tablet technology

Popis výsledku anglicky

This review focuses on the characterization of (meth)acrylate copolymers ? Eudragit?, describing their thermal treatment behaviour, possible interactions between cationic and anionic polymers, incompatibilities related to Eudragits? and their use in the pharmaceutical technology of oral tablets. In summary, Eudragit? copolymers are divided into soluble ones, insoluble ones and a combination of these two types. The combination of soluble and insoluble poly(meth)acrylate gave a new type of polymer, Eudragit? FL. In oral tablet technology, Eudragits? are widely used in matrix tablets, either alone or in combination, where they mainly provide sustained drug release. To a lesser extent, Eudragits? are used in gastroretentive systems. Moreover, Eudragits? are also of great importance in coated tablets technology, where these enteric polymers provide specific drug targeting to certain parts of the digestive tract, mainly to the small intestine or colon. Important systems such as CODESTM and MMX? technology are mentioned. Last but not least an overview table of currently available oral medicinal products on the Czech market, where at least one of the Eudragits? was used as a film-forming agent, is included

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Svazek periodika

68

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

15

Strana od-do

183-197

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85077465655