The effect of co-processed excipient physical properties on the tablet content uniformity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43878192" target="_blank" >RIV/62157124:16370/19:43878192 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The effect of co-processed excipient physical properties on the tablet content uniformity

Popis výsledku v původním jazyce

The easiest technology to produce tablets is direct compression, even though the use of the method requires overcoming many obstacles, mainly related to content uniformity (CU). Some producers offer co-processed excipients (CPE) with various density and particle size distribution. Nowadays, CPE containing commonly processed blends of fillers, binders, disintegrants and other excipients are more and more used. The aim of this work was to assess the effect of CPE physical properties on the CU of resulted tablets. To draw conclusions about mutual relations between predictors variables (CPE physical characteristics) and response variables (CU of tablets), PLS (partial least squares) was employed. The use of CPE appears to be an advantageous option for the formulation of low API tablets by direct compression method. The most important variables influencing CU proved to be a bulk density, pycnometric density and flowability.

Název v anglickém jazyce

The effect of co-processed excipient physical properties on the tablet content uniformity

Popis výsledku anglicky

The easiest technology to produce tablets is direct compression, even though the use of the method requires overcoming many obstacles, mainly related to content uniformity (CU). Some producers offer co-processed excipients (CPE) with various density and particle size distribution. Nowadays, CPE containing commonly processed blends of fillers, binders, disintegrants and other excipients are more and more used. The aim of this work was to assess the effect of CPE physical properties on the CU of resulted tablets. To draw conclusions about mutual relations between predictors variables (CPE physical characteristics) and response variables (CU of tablets), PLS (partial least squares) was employed. The use of CPE appears to be an advantageous option for the formulation of low API tablets by direct compression method. The most important variables influencing CU proved to be a bulk density, pycnometric density and flowability.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů