Nerve Agents' Surrogates: Invaluable Tools for Development of Acetylcholinesterase Reactivators

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50016114" target="_blank" >RIV/62690094:18470/19:50016114 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ingentaconnect.com/content/ben/coc/2019/00000023/00000014/art00007" target="_blank" >https://www.ingentaconnect.com/content/ben/coc/2019/00000023/00000014/art00007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1385272823666190806114017" target="_blank" >10.2174/1385272823666190806114017</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nerve Agents' Surrogates: Invaluable Tools for Development of Acetylcholinesterase Reactivators

Popis výsledku v původním jazyce

The use of nerve agents as warfare and in terrorist acts has drawn much attention from the governments and societies. Such toxic organophosphorus compounds are listed in Chemical Weapons Convention as Schedule 1 chemicals. The discussion about the chemical identity of the elusive Novichok agents, more potent compounds than best known G- and V-Agents, which have been implicated in recent rumorous assassination plots, clearly demonstrating the importance of the matter. Furthermore, accidents with pesticides or misuse thereof have been a pressing issue in many countries. In this context, the continued development of novel cholinesterase reactivators, antidotes for organophosphorus poisoning, a rather restricted class of pharmaceutical substances, is warranted. Testing of novel candidates may require use of actual nerve agents. Nonetheless, only a few laboratories comply with the requirements for storing, possession and manipulation of such toxic chemicals. To overcome such limitations, nerve agents&apos; surrogates may be a useful alternative, as they undergo the same reaction with cholinesterases, yielding similar adducts, allowing assays with novel antidote candidates, among other applications.

Název v anglickém jazyce

Nerve Agents' Surrogates: Invaluable Tools for Development of Acetylcholinesterase Reactivators

Popis výsledku anglicky

The use of nerve agents as warfare and in terrorist acts has drawn much attention from the governments and societies. Such toxic organophosphorus compounds are listed in Chemical Weapons Convention as Schedule 1 chemicals. The discussion about the chemical identity of the elusive Novichok agents, more potent compounds than best known G- and V-Agents, which have been implicated in recent rumorous assassination plots, clearly demonstrating the importance of the matter. Furthermore, accidents with pesticides or misuse thereof have been a pressing issue in many countries. In this context, the continued development of novel cholinesterase reactivators, antidotes for organophosphorus poisoning, a rather restricted class of pharmaceutical substances, is warranted. Testing of novel candidates may require use of actual nerve agents. Nonetheless, only a few laboratories comply with the requirements for storing, possession and manipulation of such toxic chemicals. To overcome such limitations, nerve agents&apos; surrogates may be a useful alternative, as they undergo the same reaction with cholinesterases, yielding similar adducts, allowing assays with novel antidote candidates, among other applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current organic chemistry

ISSN

1385-2728

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

21

Strana od-do

1539-1559

Kód UT WoS článku

000490547000006

EID výsledku v databázi Scopus

2-s2.0-85076517628