Highly Active Nanofibrous Wound Dressing Material with Barrier Function and Active Drug Release

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F64577732%3A_____%2F19%3AN0000001" target="_blank" >RIV/64577732:_____/19:N0000001 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Highly Active Nanofibrous Wound Dressing Material with Barrier Function and Active Drug Release

Popis výsledku v původním jazyce

The aim of this work is the development of highly functionalizes nanofiber material for wound dressing. A precondition for successful chronic wound treatment is to reduce contamination by microorganisms. The main idea is to prepare the wound cover for topical application an to release the drug sufficiently long to prevent frequent rewinding and other material consumption. The cover combines the properties of barrier against contamination, the carrier of active therapeutic substance with gradual release and also the breathable nanofibrous biocompatible material. The dressing material consists of nanofibrous layer made by electrospinning. The surface of nanofibres is covered with an active substance (e.g. antibiotics) enclosed to liposomes or solid lipid microparticles which provide gradual release at approx. 37 °C. Produced dressing was tested and verified by scanning electron microscopy (SEM), dynamic light scattering (DLS), release kinetics, antimicrobial tests and cytotoxicity assays.

Název v anglickém jazyce

Highly Active Nanofibrous Wound Dressing Material with Barrier Function and Active Drug Release

Popis výsledku anglicky

The aim of this work is the development of highly functionalizes nanofiber material for wound dressing. A precondition for successful chronic wound treatment is to reduce contamination by microorganisms. The main idea is to prepare the wound cover for topical application an to release the drug sufficiently long to prevent frequent rewinding and other material consumption. The cover combines the properties of barrier against contamination, the carrier of active therapeutic substance with gradual release and also the breathable nanofibrous biocompatible material. The dressing material consists of nanofibrous layer made by electrospinning. The surface of nanofibres is covered with an active substance (e.g. antibiotics) enclosed to liposomes or solid lipid microparticles which provide gradual release at approx. 37 °C. Produced dressing was tested and verified by scanning electron microscopy (SEM), dynamic light scattering (DLS), release kinetics, antimicrobial tests and cytotoxicity assays.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

<a href="/cs/project/FV10605" target="_blank" >FV10605: Vysoce funkční nanovlákenný obvazový materiál s bariérovou funkcí a aktivním uvolňováním léčiva</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů