Dipeptidyl peptidase IV in two human glioma cell lines.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F00%3A20010202" target="_blank" >RIV/67985823:_____/00:20010202 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/01:23010439

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dipeptidyl peptidase IV in two human glioma cell lines.

Popis výsledku v původním jazyce

Dipeptidyl peptidase IV (DPP-IV) takes part in the metabolism of biologically active peptides participating in the regulation of growth and transformation of glial cells. However, the knowledge on the DPP-IV expression in human glial and glioma cells isstill very limited. In this study, using histochemical and biochemical techniques, the DPP-IV activity was demonstrated in 2 human glioma cell lines of different transformation degree, as represented by U373 astrocytoma (WHO Grade III) and U87 glioblastoma multiforme (WHO Grade IV) lines. Higher total activity of the enzyme, as well as its preferential localisation in the plasma membrane, was observed in U 87 cells. Compared to U 373 population, U 87 cells were morphogically more pleiomorphic, their were less cycling and expressing less GFAP. The data suggests positive correlation between the degree of transformation of cells and activity of DPP IV. The differential expression of this enzyme makes these lines a suitable and standard mod

Název v anglickém jazyce

Dipeptidyl peptidase IV in two human glioma cell lines.

Popis výsledku anglicky

Dipeptidyl peptidase IV (DPP-IV) takes part in the metabolism of biologically active peptides participating in the regulation of growth and transformation of glial cells. However, the knowledge on the DPP-IV expression in human glial and glioma cells isstill very limited. In this study, using histochemical and biochemical techniques, the DPP-IV activity was demonstrated in 2 human glioma cell lines of different transformation degree, as represented by U373 astrocytoma (WHO Grade III) and U87 glioblastoma multiforme (WHO Grade IV) lines. Higher total activity of the enzyme, as well as its preferential localisation in the plasma membrane, was observed in U 87 cells. Compared to U 373 population, U 87 cells were morphogically more pleiomorphic, their were less cycling and expressing less GFAP. The data suggests positive correlation between the degree of transformation of cells and activity of DPP IV. The differential expression of this enzyme makes these lines a suitable and standard mod

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/LN00A026" target="_blank" >LN00A026: Centrum molekulární a buněčné imunologie</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Histochemistry

ISSN

1121-760X

e-ISSN

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Svazek periodika

44

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

7

Strana od-do

57-63

Kód UT WoS článku

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EID výsledku v databázi Scopus

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