Expression of attractin and its differential enzyme activity in glioma cells.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010208" target="_blank" >RIV/67985823:_____/01:20010208 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Expression of attractin and its differential enzyme activity in glioma cells.

Popis výsledku v původním jazyce

Attractin/mahogany is a multifunctional protein involved in a number of physiological and pathological functions. Human attractin has an enzyme activity resembling dipeptidyl peptidase IV (DPP-IV). In the nervous system, the protein has been detected inneurons but not in glial cells up to now. In this study we provide evidence on expression of both attractin mRNA and protein in 3 glioma cell lines (WHO Grade I rat C6 cells, WHO Grade III and IV human U373 and U87 cells). The protein possesed the DPP-IV-like activity in only human U373 and particularly U87 cells. It was bound almost exclusively plasma membrane and represented 5 and 25 of the total cellular DPP-IV-like enzyme activity pool in both these lines. The functional role of attractin, as well as its enzymatic activity, in glioma cells remains unclear. The data suggests its participation in growth properties of tumors of glial origin.

Název v anglickém jazyce

Expression of attractin and its differential enzyme activity in glioma cells.

Popis výsledku anglicky

Attractin/mahogany is a multifunctional protein involved in a number of physiological and pathological functions. Human attractin has an enzyme activity resembling dipeptidyl peptidase IV (DPP-IV). In the nervous system, the protein has been detected inneurons but not in glial cells up to now. In this study we provide evidence on expression of both attractin mRNA and protein in 3 glioma cell lines (WHO Grade I rat C6 cells, WHO Grade III and IV human U373 and U87 cells). The protein possesed the DPP-IV-like activity in only human U373 and particularly U87 cells. It was bound almost exclusively plasma membrane and represented 5 and 25 of the total cellular DPP-IV-like enzyme activity pool in both these lines. The functional role of attractin, as well as its enzymatic activity, in glioma cells remains unclear. The data suggests its participation in growth properties of tumors of glial origin.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochemical and Biophysical Research Communications

ISSN

0006-291X

e-ISSN

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Svazek periodika

284

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

289-294

Kód UT WoS článku

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EID výsledku v databázi Scopus

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