Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F12%3A00381846" target="_blank" >RIV/67985823:_____/12:00381846 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1371/journal.pone.0046951" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0046951</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0046951" target="_blank" >10.1371/journal.pone.0046951</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats

Popis výsledku v původním jazyce

The study analyzed the function of the circadian system of Spontaneously hypertensive rat (SHR). The results revealed that SHR exhibited an early chronotype, because the central clock in the suprachiasmaric nuclei of the hypothalamus was phase-advanced relative to light/dark cycle. Moreover, the output rhythm was dampened. The peripheral clocks of SHR reacted to the dampened central clock with tissue-specific consequences. In the colon, the rhythms were severely altered, whereas the effect was only marginal in the liver. These results might result in mutual desynchrony of circadian oscillators within the circadian system of SHR, thereby potentially contributing to metabolic pathology of the rat strain

Název v anglickém jazyce

Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats

Popis výsledku anglicky

The study analyzed the function of the circadian system of Spontaneously hypertensive rat (SHR). The results revealed that SHR exhibited an early chronotype, because the central clock in the suprachiasmaric nuclei of the hypothalamus was phase-advanced relative to light/dark cycle. Moreover, the output rhythm was dampened. The peripheral clocks of SHR reacted to the dampened central clock with tissue-specific consequences. In the colon, the rhythms were severely altered, whereas the effect was only marginal in the liver. These results might result in mutual desynchrony of circadian oscillators within the circadian system of SHR, thereby potentially contributing to metabolic pathology of the rat strain

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

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Kód UT WoS článku

000309452600065

EID výsledku v databázi Scopus

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