Effects of type 1 diabetes on sleep duration and timing – a comparison within the general population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F25%3A00640549" target="_blank" >RIV/67985823:_____/25:00640549 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378025:_____/25:00640549 RIV/00023001:_____/25:00085926 RIV/00216208:11110/25:10505024

Výsledek na webu

<a href="https://doi.org/10.1016/j.sleep.2025.106868" target="_blank" >https://doi.org/10.1016/j.sleep.2025.106868</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sleep.2025.106868" target="_blank" >10.1016/j.sleep.2025.106868</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of type 1 diabetes on sleep duration and timing – a comparison within the general population

Popis výsledku v původním jazyce

Study objectives:The role of circadian misalignment has been implicated in metabolic health, not excluding glycemic control, but its role in type 1 diabetes mellitus (T1DM) has not been fully understood. The aim of the study was to investigate the relationship between the degree of circadian misalignment and the efficacy of glycemic control in T1DM patients.Methods:This cross-sectional study included 879 patients within the general Czech population who have been diagnosed with T1DM for a period of at least 10 years (mean HbA1C 52.9 ± 0.4 mmol/mol). The patients were aged 18–86 years and comprised 45 % females. All participants filled out the Munich Chronotype Questionnaire (MCTQ) to assess their individual chronotype and calculate social jetlag (SJL). The individual chronotypes were also assessed using self-reporting best alertness time (BAmid). Sleep quality was self-assessed on a 4-point scale from 1 (best) to 4 (worst). T1DM management was evaluated through continuous glucose monitoring data (CGM) including the glycemia risk index (GRI). For the non-diabetic control group, we utilized data obtained from wave 5 of a nationally representative longitudinal Czech Household Panel Survey (CHPS), which involved 1757 subjects without diabetes aged 18–86 years. Data were analyzed through cross-sectional univariate and multivariate analyses.Results:T1DM patients had later average chronotype and significantly higher SJL compared to controls. Across all adjusted models, higher SJL was consistently associated with T1DM. Within the T1DM cohort, increased SJL was positively associated with higher GRI (r = 0.12, P = 0.0029), while chronotype itself showed no independent association with glycemic control. Overall, metabolic markers showed better outcomes in T1DM patients than in control non-diabetic population.Conclusions:Social jetlag was robustly correlated with both T1DM and impaired glycemic management. These findings call for systematic examination of such characteristics in patients with T1DM and may open the door to taking circadian aspects into account when striving for optimal management of T1DM.

Název v anglickém jazyce

Effects of type 1 diabetes on sleep duration and timing – a comparison within the general population

Popis výsledku anglicky

Study objectives:The role of circadian misalignment has been implicated in metabolic health, not excluding glycemic control, but its role in type 1 diabetes mellitus (T1DM) has not been fully understood. The aim of the study was to investigate the relationship between the degree of circadian misalignment and the efficacy of glycemic control in T1DM patients.Methods:This cross-sectional study included 879 patients within the general Czech population who have been diagnosed with T1DM for a period of at least 10 years (mean HbA1C 52.9 ± 0.4 mmol/mol). The patients were aged 18–86 years and comprised 45 % females. All participants filled out the Munich Chronotype Questionnaire (MCTQ) to assess their individual chronotype and calculate social jetlag (SJL). The individual chronotypes were also assessed using self-reporting best alertness time (BAmid). Sleep quality was self-assessed on a 4-point scale from 1 (best) to 4 (worst). T1DM management was evaluated through continuous glucose monitoring data (CGM) including the glycemia risk index (GRI). For the non-diabetic control group, we utilized data obtained from wave 5 of a nationally representative longitudinal Czech Household Panel Survey (CHPS), which involved 1757 subjects without diabetes aged 18–86 years. Data were analyzed through cross-sectional univariate and multivariate analyses.Results:T1DM patients had later average chronotype and significantly higher SJL compared to controls. Across all adjusted models, higher SJL was consistently associated with T1DM. Within the T1DM cohort, increased SJL was positively associated with higher GRI (r = 0.12, P = 0.0029), while chronotype itself showed no independent association with glycemic control. Overall, metabolic markers showed better outcomes in T1DM patients than in control non-diabetic population.Conclusions:Social jetlag was robustly correlated with both T1DM and impaired glycemic management. These findings call for systematic examination of such characteristics in patients with T1DM and may open the door to taking circadian aspects into account when striving for optimal management of T1DM.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sleep Medicine

ISSN

1389-9457

e-ISSN

1878-5506

Svazek periodika

136

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

106868

Kód UT WoS článku

001603927600001

EID výsledku v databázi Scopus

2-s2.0-105020988493