Electrospinning of PCL/CEFUROXIM® fibrous scaffolds on 3D printed collectors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F20%3A00573189" target="_blank" >RIV/67985858:_____/20:00573189 - isvavai.cz</a>

Výsledek na webu

<a href="https://hdl.handle.net/11104/0343646" target="_blank" >https://hdl.handle.net/11104/0343646</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00405000.2019.1707347" target="_blank" >10.1080/00405000.2019.1707347</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrospinning of PCL/CEFUROXIM® fibrous scaffolds on 3D printed collectors

Popis výsledku v původním jazyce

In this paper, the effect of different collector geometry on the PCL scaffold architecture and cell viability was investigated. PCL scaffolds with antibiotic CefuroximVR, 15%wt. and 20%wt., were electrospun and characterized by ATR-FTIR, while thermal stability were observed by DSC and TG. PCL/15%CFUVR scaffolds were electrospun on six 3D printed collectors, three ribbed and three mesh geometries, to produce the most favourable structure for cells adhesion and proliferation. SEM study and MTT assay revealed that collectors with the widest slot in both ribbed and mesh geometries exhibited the most favourable structure to enhance cells adhesion. In general, cells spreading on the surface and cells via bility proved to be better for the ribbed collectors. The study showed that by controlling the collector geometry and the scaffold three-dimensional structure, it is possible to control cell attachment and differentiation and, consequently, to adjust them for the special tissue demands in the regeneration process.

Název v anglickém jazyce

Electrospinning of PCL/CEFUROXIM® fibrous scaffolds on 3D printed collectors

Popis výsledku anglicky

In this paper, the effect of different collector geometry on the PCL scaffold architecture and cell viability was investigated. PCL scaffolds with antibiotic CefuroximVR, 15%wt. and 20%wt., were electrospun and characterized by ATR-FTIR, while thermal stability were observed by DSC and TG. PCL/15%CFUVR scaffolds were electrospun on six 3D printed collectors, three ribbed and three mesh geometries, to produce the most favourable structure for cells adhesion and proliferation. SEM study and MTT assay revealed that collectors with the widest slot in both ribbed and mesh geometries exhibited the most favourable structure to enhance cells adhesion. In general, cells spreading on the surface and cells via bility proved to be better for the ribbed collectors. The study showed that by controlling the collector geometry and the scaffold three-dimensional structure, it is possible to control cell attachment and differentiation and, consequently, to adjust them for the special tissue demands in the regeneration process.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Textile Institute

ISSN

0040-5000

e-ISSN

1754-2340

Svazek periodika

111

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

1288-1299

Kód UT WoS článku

000506136600001

EID výsledku v databázi Scopus

2-s2.0-85078636496