Effects of aqueous systems and stabilization membranes on the separation of an antibiotic precursor in a microextractor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F22%3A00561869" target="_blank" >RIV/67985858:_____/22:00561869 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/22:43925223

Výsledek na webu

<a href="https://hdl.handle.net/11104/0334333" target="_blank" >https://hdl.handle.net/11104/0334333</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.seppur.2022.121050" target="_blank" >10.1016/j.seppur.2022.121050</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of aqueous systems and stabilization membranes on the separation of an antibiotic precursor in a microextractor

Popis výsledku v původním jazyce

Small-scale, continuous separation and purification of fine chemicals of pharmaceutical value represent a challenging engineering task. Currently available slug-flow and parallel-flow microfluidic extractors suffer from instabilities of the liquid-liquid interface and difficult realization of the counter-current arrangement. To tackle this challenge, we constructed a robust microfluidic membrane extractor, which was realized as a membrane tube-in-a-shell system operating in a wide range of extraction conditions. We tested the microextractor performance on separating 7-aminodeacetoxycephalosporanic acid (7-ADCA), an essential precursor of beta-lactam antibiotics. Aqueous two-phase system (ATPS) and a system of identical aqueous phases were used in a series of extraction experiments. Expectedly, we found that the counter-current arrangement provides an almost 100 % yield of 7-ADCA. The enhanced 7-ADCA enrichment anticipated in the selected ATPS thanks to favorable 7-ADCA partitioning was only reached at longer residence times. Lower mass transport resistances occurring in low viscous aqueous phases turned out to have a primary effect on the extraction characteristics. A detailed analysis of transport resistances also revealed that the contribution of the tubular membrane to the overall mass transport resistance is low. This important finding indicates that microcontactors with thin integrated membranes are a promising option for micro-or milli-plants when fine chemicals are continuously produced.

Název v anglickém jazyce

Effects of aqueous systems and stabilization membranes on the separation of an antibiotic precursor in a microextractor

Popis výsledku anglicky

Small-scale, continuous separation and purification of fine chemicals of pharmaceutical value represent a challenging engineering task. Currently available slug-flow and parallel-flow microfluidic extractors suffer from instabilities of the liquid-liquid interface and difficult realization of the counter-current arrangement. To tackle this challenge, we constructed a robust microfluidic membrane extractor, which was realized as a membrane tube-in-a-shell system operating in a wide range of extraction conditions. We tested the microextractor performance on separating 7-aminodeacetoxycephalosporanic acid (7-ADCA), an essential precursor of beta-lactam antibiotics. Aqueous two-phase system (ATPS) and a system of identical aqueous phases were used in a series of extraction experiments. Expectedly, we found that the counter-current arrangement provides an almost 100 % yield of 7-ADCA. The enhanced 7-ADCA enrichment anticipated in the selected ATPS thanks to favorable 7-ADCA partitioning was only reached at longer residence times. Lower mass transport resistances occurring in low viscous aqueous phases turned out to have a primary effect on the extraction characteristics. A detailed analysis of transport resistances also revealed that the contribution of the tubular membrane to the overall mass transport resistance is low. This important finding indicates that microcontactors with thin integrated membranes are a promising option for micro-or milli-plants when fine chemicals are continuously produced.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20402 - Chemical process engineering

Projekt

<a href="/cs/project/GA20-09980S" target="_blank" >GA20-09980S: Mikrofluidní reaktory s vloženými semi-permeabilními membránami pro přípravu speciálních chemikálií</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Separation and Purification Technology

ISSN

1383-5866

e-ISSN

1873-3794

Svazek periodika

292

Číslo periodika v rámci svazku

JUL 1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

121050

Kód UT WoS článku

000855029400004

EID výsledku v databázi Scopus

2-s2.0-85128280496