Demographic and selection histories of populations across the Sahel/Savannah belt

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985912%3A_____%2F22%3A00563470" target="_blank" >RIV/67985912:_____/22:00563470 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/22:10449903

Výsledek na webu

<a href="https://academic.oup.com/mbe/article/39/10/msac209/6731090" target="_blank" >https://academic.oup.com/mbe/article/39/10/msac209/6731090</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/molbev/msac209" target="_blank" >10.1093/molbev/msac209</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Demographic and selection histories of populations across the Sahel/Savannah belt

Popis výsledku v původním jazyce

The study shows very complex patterns of genetic diversity between the populations from the Sahel/Savannah belt. The new findings improve our current knowledge of population structure, migration, admixture, and also adaptation of different human populations and shed new light on how selection may have influenced human adaptation to diseases, cultural factors, and environmental changes in Africa. The study also investigated genomic regions that were candidates for selection. For instance, in a population from Senegal (the Bedik) involved genes are associated with several rare blood disorders. Other Western African populations showed candidate regions of selection that were associated with malaria genes, lactase persistence, and immune response. In particular, a specific signal of exceptionally strong selection was detected in Eastern Sahel (the Rashaayda Arab) and this region involves the CNR1 gene, which was previously associated with substance dependence and responses to chronic stress. These findings are discussed in relation to archaeological and historical evidence regarding migrations and demographic changes in this part of Africa.

Název v anglickém jazyce

Demographic and selection histories of populations across the Sahel/Savannah belt

Popis výsledku anglicky

The study shows very complex patterns of genetic diversity between the populations from the Sahel/Savannah belt. The new findings improve our current knowledge of population structure, migration, admixture, and also adaptation of different human populations and shed new light on how selection may have influenced human adaptation to diseases, cultural factors, and environmental changes in Africa. The study also investigated genomic regions that were candidates for selection. For instance, in a population from Senegal (the Bedik) involved genes are associated with several rare blood disorders. Other Western African populations showed candidate regions of selection that were associated with malaria genes, lactase persistence, and immune response. In particular, a specific signal of exceptionally strong selection was detected in Eastern Sahel (the Rashaayda Arab) and this region involves the CNR1 gene, which was previously associated with substance dependence and responses to chronic stress. These findings are discussed in relation to archaeological and historical evidence regarding migrations and demographic changes in this part of Africa.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

60102 - Archaeology

Projekt

<a href="/cs/project/GA19-09352S" target="_blank" >GA19-09352S: Genomické adaptace a molekulární ekologie potravně produkčních systémů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Biology and Evolution

ISSN

0737-4038

e-ISSN

1537-1719

Svazek periodika

39

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

19

Strana od-do

msac209

Kód UT WoS článku

000870423900001

EID výsledku v databázi Scopus

2-s2.0-85152066341