Half-sandwich type rhodium(III)-aminohydroxamate complexes: the role of the position of the amino group in metal ion binding

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F18%3A00502720" target="_blank" >RIV/68081707:_____/18:00502720 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/18:73589836

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c7nj04711h" target="_blank" >http://dx.doi.org/10.1039/c7nj04711h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c7nj04711h" target="_blank" >10.1039/c7nj04711h</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Half-sandwich type rhodium(III)-aminohydroxamate complexes: the role of the position of the amino group in metal ion binding

Popis výsledku v původním jazyce

Complex formation equilibria between [(eta(5)-Cp*) Rh-III(H2O)(3)](2+) and aminohydroxamic acids (L-2-aminoN-hydroxyacetamide (alpha-alahaH), 3-amino-N-hydroxypropanamide (beta-alahaH) and 4-amino-N-hydroxybutanamide (GABAha, gamma-abhaH)) having the primary amino group in different chelatable positions relative to the hydroxamic function were studied using pH-potentiometric, H-1 NMR and ESI-MS methods and the formation constants of the complexes present in aqueous solution are reported. The relative order of the pH-dependent conditional stability of the hydroxamate type (O,O) and (N-amino, N-hydroxamato) chelates was found to determine to a great extent the coordination modes both in the mono-and various dinuclear species formed. While with alpha-alaha(-), a 5-membered (N,N) chelated mononuclear complex predominates, with beta-alaha-in a wide pH-range, very stable dinuclear cluster ions exist. With gamma-abha(-), in the most stable complexes, two ligands (in reverse variation) link two half-sandwich cations, coordinating each ligand via the hydroxamate chelate to one metal centre, while via the amino-N to the other one. This arrangement seems to be further stabilized by a hydrogen bond as DFT calculations support the extra stabilization effect of internal H-bonding in [{(eta(5)-Cp*) Rh-III}(2)H1(gamma-abha)(2)](+). The synthesis, spectral (NMR and IR) and MS characterization of a novel complex with an iridium analogue, [(eta(5)-Cp*) Ir-III(alpha-alaha) Br] (1) is also described. This complex was tested for its in vitro cytotoxicity using human-derived cancer cell lines (A2780, HeLa, DU-145, A549, and MCF-7) and showed insignificant anti-proliferative activity in the micromolar concentration range.

Název v anglickém jazyce

Half-sandwich type rhodium(III)-aminohydroxamate complexes: the role of the position of the amino group in metal ion binding

Popis výsledku anglicky

Complex formation equilibria between [(eta(5)-Cp*) Rh-III(H2O)(3)](2+) and aminohydroxamic acids (L-2-aminoN-hydroxyacetamide (alpha-alahaH), 3-amino-N-hydroxypropanamide (beta-alahaH) and 4-amino-N-hydroxybutanamide (GABAha, gamma-abhaH)) having the primary amino group in different chelatable positions relative to the hydroxamic function were studied using pH-potentiometric, H-1 NMR and ESI-MS methods and the formation constants of the complexes present in aqueous solution are reported. The relative order of the pH-dependent conditional stability of the hydroxamate type (O,O) and (N-amino, N-hydroxamato) chelates was found to determine to a great extent the coordination modes both in the mono-and various dinuclear species formed. While with alpha-alaha(-), a 5-membered (N,N) chelated mononuclear complex predominates, with beta-alaha-in a wide pH-range, very stable dinuclear cluster ions exist. With gamma-abha(-), in the most stable complexes, two ligands (in reverse variation) link two half-sandwich cations, coordinating each ligand via the hydroxamate chelate to one metal centre, while via the amino-N to the other one. This arrangement seems to be further stabilized by a hydrogen bond as DFT calculations support the extra stabilization effect of internal H-bonding in [{(eta(5)-Cp*) Rh-III}(2)H1(gamma-abha)(2)](+). The synthesis, spectral (NMR and IR) and MS characterization of a novel complex with an iridium analogue, [(eta(5)-Cp*) Ir-III(alpha-alaha) Br] (1) is also described. This complex was tested for its in vitro cytotoxicity using human-derived cancer cell lines (A2780, HeLa, DU-145, A549, and MCF-7) and showed insignificant anti-proliferative activity in the micromolar concentration range.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

New Journal of Chemistry

ISSN

1144-0546

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

7659-7670

Kód UT WoS článku

000434245500019

EID výsledku v databázi Scopus

—