Biocompatibility of colloidal polypyrrole
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00583313" target="_blank" >RIV/68081707:_____/23:00583313 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/70883521:28110/23:63570158 RIV/70883521:28610/23:63570158
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S0927776523004836?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0927776523004836?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfb.2023.113605" target="_blank" >10.1016/j.colsurfb.2023.113605</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Biocompatibility of colloidal polypyrrole
Popis výsledku v původním jazyce
The excellent electroconductive properties of polypyrrole (PPy) predetermine its use as cell-instructive or bio-sensing biomaterial. PPy has potential for application in a physiological environment, and here the cytotoxicity, antioxidant capacity, modulation of neutrophil oxidative burst, antibacterial activity of colloidal PPy stabilized with polyvinylpyrrolidone (PVP), and long-term stability under physiological conditions are reported. Besides, long-term stability under physiological conditions is also provided. The formation of PPy/PVP colloid was proven by UV-Vis and IR spectroscopy, and its morphology and particle size were detected. The results of cytotoxicity studies show that the safe PPy concentration in colloidal particles for biomedical usage is <= 200 mu g mL-1. In these concentrations, the PPy/PVP also exhibits excellent antioxidant properties and modulates the immune response. The minimal inhibitory concentration of 234 mu g mL-1 was determined against Staphylococcus aureus and Escherichia coli, respectively. The low cytotoxicity and bioactivity of the colloidal PPy/PVP demonstrate their long-term potential for a variety of applications
Název v anglickém jazyce
Biocompatibility of colloidal polypyrrole
Popis výsledku anglicky
The excellent electroconductive properties of polypyrrole (PPy) predetermine its use as cell-instructive or bio-sensing biomaterial. PPy has potential for application in a physiological environment, and here the cytotoxicity, antioxidant capacity, modulation of neutrophil oxidative burst, antibacterial activity of colloidal PPy stabilized with polyvinylpyrrolidone (PVP), and long-term stability under physiological conditions are reported. Besides, long-term stability under physiological conditions is also provided. The formation of PPy/PVP colloid was proven by UV-Vis and IR spectroscopy, and its morphology and particle size were detected. The results of cytotoxicity studies show that the safe PPy concentration in colloidal particles for biomedical usage is <= 200 mu g mL-1. In these concentrations, the PPy/PVP also exhibits excellent antioxidant properties and modulates the immune response. The minimal inhibitory concentration of 234 mu g mL-1 was determined against Staphylococcus aureus and Escherichia coli, respectively. The low cytotoxicity and bioactivity of the colloidal PPy/PVP demonstrate their long-term potential for a variety of applications
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10610 - Biophysics
Návaznosti výsledku
Projekt
<a href="/cs/project/GA23-07425S" target="_blank" >GA23-07425S: Anisotropní a elektricky vodivé biomateriály</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Colloids and Surfaces B-Biointerfaces
ISSN
0927-7765
e-ISSN
1873-4367
Svazek periodika
232
Číslo periodika v rámci svazku
December 2023
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
10
Strana od-do
113605
Kód UT WoS článku
001102656700001
EID výsledku v databázi Scopus
2-s2.0-85175161602