Biocompatibility of colloidal polypyrrole

Kód výsledku v IS VaVaI

RIV/68081707:_____/23:00583313 - isvavai.cz

Nalezeny alternativní kódy

RIV/70883521:28110/23:63570158 RIV/70883521:28610/23:63570158

Výsledek na webu

https://www.sciencedirect.com/science/article/pii/S0927776523004836?via%3Dihub

DOI - Digital Object Identifier

10.1016/j.colsurfb.2023.113605

Jazyk výsledku

angličtina

Název v původním jazyce

Biocompatibility of colloidal polypyrrole

Popis výsledku v původním jazyce

The excellent electroconductive properties of polypyrrole (PPy) predetermine its use as cell-instructive or bio-sensing biomaterial. PPy has potential for application in a physiological environment, and here the cytotoxicity, antioxidant capacity, modulation of neutrophil oxidative burst, antibacterial activity of colloidal PPy stabilized with polyvinylpyrrolidone (PVP), and long-term stability under physiological conditions are reported. Besides, long-term stability under physiological conditions is also provided. The formation of PPy/PVP colloid was proven by UV-Vis and IR spectroscopy, and its morphology and particle size were detected. The results of cytotoxicity studies show that the safe PPy concentration in colloidal particles for biomedical usage is <= 200 mu g mL-1. In these concentrations, the PPy/PVP also exhibits excellent antioxidant properties and modulates the immune response. The minimal inhibitory concentration of 234 mu g mL-1 was determined against Staphylococcus aureus and Escherichia coli, respectively. The low cytotoxicity and bioactivity of the colloidal PPy/PVP demonstrate their long-term potential for a variety of applications

Název v anglickém jazyce

Biocompatibility of colloidal polypyrrole

Popis výsledku anglicky

The excellent electroconductive properties of polypyrrole (PPy) predetermine its use as cell-instructive or bio-sensing biomaterial. PPy has potential for application in a physiological environment, and here the cytotoxicity, antioxidant capacity, modulation of neutrophil oxidative burst, antibacterial activity of colloidal PPy stabilized with polyvinylpyrrolidone (PVP), and long-term stability under physiological conditions are reported. Besides, long-term stability under physiological conditions is also provided. The formation of PPy/PVP colloid was proven by UV-Vis and IR spectroscopy, and its morphology and particle size were detected. The results of cytotoxicity studies show that the safe PPy concentration in colloidal particles for biomedical usage is <= 200 mu g mL-1. In these concentrations, the PPy/PVP also exhibits excellent antioxidant properties and modulates the immune response. The minimal inhibitory concentration of 234 mu g mL-1 was determined against Staphylococcus aureus and Escherichia coli, respectively. The low cytotoxicity and bioactivity of the colloidal PPy/PVP demonstrate their long-term potential for a variety of applications

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

GA23-07425S: Anisotropní a elektricky vodivé biomateriály

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Colloids and Surfaces B-Biointerfaces

ISSN

0927-7765

e-ISSN

1873-4367

Svazek periodika

232

Číslo periodika v rámci svazku

December 2023

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

113605

Kód UT WoS článku

001102656700001

EID výsledku v databázi Scopus

2-s2.0-85175161602